Evidence map›Paper›PMID 36011372›Full record

ArticleGenes2022

A Mouse Model with Ablated Asparaginase and Isoaspartyl Peptidase 1 (

Pooja Biswas, Anne Marie Berry, Qais Zawaydeh, Dirk-Uwe G Bartsch, Pongali B Raghavendra, J Fielding Hejtmancik, Naheed W Khan, S Amer Riazuddin, Radha Ayyagari

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Pooja BiswasShiley Eye Institute, University of California San Diego, La Jolla, CA 92093, USA.
Anne Marie BerryShiley Eye Institute, University of California San Diego, La Jolla, CA 92093, USA.
Qais ZawaydehShiley Eye Institute, University of California San Diego, La Jolla, CA 92093, USA.
Dirk-Uwe G BartschShiley Eye Institute, University of California San Diego, La Jolla, CA 92093, USA.
Pongali B RaghavendraSchool of Biotechnology, REVA University, Bengaluru 560064, India.
J Fielding HejtmancikNational Eye Institute, National Institute of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-4788-0362
Naheed W KhanOphthalmology and Visual Sciences, University of Michigan Health, Michigan Medicine, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4903-2065
S Amer RiazuddinWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 20817, USA.
Radha AyyagariShiley Eye Institute, University of California San Diego, La Jolla, CA 92093, USA.
University of California San Diego · USJohns Hopkins University · USMichigan Medicine · USNational Eye Institute · USNational Institute of Biomedical Genomics · IN

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Derek Stuart Welsbie · 2012 to 2026
$10.3M
Molecular Basis of Hereditary Retinal DegenerationsR01EY021237 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AYYAGARI, RADHA · 2011 to 2020
$5.6M
Mechanistic-Based Non-Invasive Assessment of Retinal Damage in HAART EraR01EY016323 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARTSCH, DIRK-UWE G · 2006 to 2020
$5.0M
Unraveling the molecular pathology of retinal degeneration through single cell genomicsR01EY031663 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AYYAGARI, RADHA, FRAZER, KELLY A · 2021 to 2025
$3.3M
Molecular mechanism underlying late-onset retinal/macular degenerationR01EY030591 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AYYAGARI, RADHA · 2020 to 2023
$1.9M
Translational Vision Research Training at UCSDT32EY026590 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2016 to 2025
$854k
NCI NIH HHS P30 CA023100NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY016323NEI NIH HHS R01 EY021237NEI NIH HHS R01 EY030591NEI NIH HHS R01 EY031663NEI NIH HHS T32 EY026590NIH HHS RO1EY030591NIH HHS RO1EY031663NIH HHS RO1EY21237The Foundation Fighting Blindness T32EY026590
6 · The paper itself

Abstract

We previously identified a homozygous G178R mutation in human

Indexed as

AutoantigensRetinal DegenerationAnimalsAsparaginaseDisease Models, AnimalEscherichia coliHumansInfantMiceMice, Inbred C57BLPeptide HydrolasesPhenotypeAsparaginaseasrgl1 protein, mouseAutoantigensPeptide Hydrolasesanimal modelASRGL1CRISPR/Cas9early onset degeneration

Identifiers

PMID36011372
PMCPMC9408336
OpenAlexW4292080011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.