Evidence map›Paper›PMID 36011371›Full record

ArticleGenes2022

Molecular Dynamic Simulation Reveals Structure Differences in

Richard Mayanja, Christopher Kintu, Oudou Diabate, Opeyemi Soremekun, Olugbenga Oluseun Oluwagbemi, Mamadou Wele, Robert Kalyesubula, Daudi Jjingo, Tinashe Chikowore, Segun Fatumo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Richard MayanjaThe African Computational Genomics (TACG) Research Group, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe 31405, Uganda.
Christopher KintuThe African Computational Genomics (TACG) Research Group, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe 31405, Uganda.
Oudou DiabateThe African Computational Genomics (TACG) Research Group, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe 31405, Uganda.
Opeyemi SoremekunThe African Computational Genomics (TACG) Research Group, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe 31405, Uganda.
Olugbenga Oluseun OluwagbemiDepartment of Computer Science and Information Technology, Sol Plaatje University, Kimberley 8301, South Africa.
Mamadou WeleAfrican Center of Excellence in Bioinformatics (ACE-B), University of Science, Technique and Technologies of Bamako (USTTB), Bamako 3206, Mali.
Robert KalyesubulaDepartment of Internal Medicine and Department of Physiology, Makerere University, Kampala 10101, Uganda.ORCID 0000-0003-3211-163X
Daudi JjingoAfrican Center of Excellence in Bioinformatics (ACE-B), Makerere University, Kampala 10101, Uganda.
Tinashe ChikoworeMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa.ORCID 0000-0002-6743-751X
Segun FatumoThe African Computational Genomics (TACG) Research Group, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe 31405, Uganda.ORCID 0000-0003-4525-3362
Makerere University · UGUniversité des Sciences, des Techniques et des Technologies de Bamako · MLLondon School of Hygiene & Tropical Medicine · GBSol Plaatje University · ZAUganda Virus Research Institute · UGUniversity of the Witwatersrand · ZA

Funding

Computational and Molecular Epidemiology Training in TB and HIV in UgandaD43TW010045 · FIC · UNIVERSITY OF GEORGIA · PI WHALEN, CHRISTOPHER C. · 2015 to 2019
$1.5M
NURTURING GENOMICS AND BIOINFORMATICS RESEARCH CAPACITY IN AFRICA (BRecA)U2RTW010672 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI JJINGO, DAUDI, KATEETE, DAVID PATRICK · 2017 to 2022
$1.3M
Transgenerational Epigenomics of Trauma and PTSD in RwandaU01MH115485 · NIMH · NATIONAL UNIVERSITY OF RWANDA · PI JANSEN, STEFAN, MUTESA, LEON · 2017 to 2021
$1.3M
West African Center of Excellence for Global Health Bioinformatics Research TrainingU2RTW010673 · FIC · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · PI DOUMBIA, SEYDOU, LI, JIAN · 2017 to 2021
$1.2M
FIC NIH HHS D43 TW010045FIC NIH HHS U2R TW010672FIC NIH HHS U2R TW010673NIMH NIH HHS U01 MH115485Wellcome TrustWellcome Trust 214205/Z/18/ZWellcome Trust 220740/Z/20/Z
6 · The paper itself

Abstract

backgroundAccording to observational studies, two polymorphisms in the apolipoprotein L1 (

methodsTo predict the active site and allosteric site on the

resultsAccording to CASTp's active site characterization, the topmost predicted site had a surface area of 964.892 Å

conclusionUsing a combination of different computational techniques, we identified binding sites within the

Indexed as

Apolipoprotein L1Renal Insufficiency, ChronicBlack PeopleHumansMolecular Dynamics SimulationMutation, MissenseAPOL1 protein, humanApolipoprotein L1APOL1chronic kidney diseasemolecular dockingmolecular dynamic simulationmutation

Identifiers

PMID36011371
PMCPMC9408642
OpenAlexW4292295035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.