Evidence map›Paper›PMID 36011331›Full record

ArticleGenes2022

microRNA Expression Profile of Purified Alveolar Epithelial Type II Cells.

Stefan Dehmel, Katharina J Weiss, Natalia El-Merhie, Jens Callegari, Birte Konrad, Kathrin Mutze, Oliver Eickelberg, Melanie Königshoff, Susanne Krauss-Etschmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Stefan DehmelInstitute for Lung Biology and Disease, Ludwig-Maximilians University Hospital Munich, Asklepios Clinic Gauting and Helmholtz Zentrum München, Comprehensive Pneumology Center Munich, Max-Lebsche-Platz 31, 81377 Munich, Germany.
Katharina J WeissInstitute for Lung Biology and Disease, Ludwig-Maximilians University Hospital Munich, Asklepios Clinic Gauting and Helmholtz Zentrum München, Comprehensive Pneumology Center Munich, Max-Lebsche-Platz 31, 81377 Munich, Germany.
Natalia El-MerhieEarly Life Origins of Chronic Lung Disease, Research Center Borstel, Leibniz Lung Center, Member of the German Center for Lung Research (DZL) and the Airway Research Center North (ARCN), 23845 Borstel, Germany.ORCID 0000-0002-0682-4022
Jens CallegariHelmholtz Zentrum Munich, Lung Repair and Regeneration, Comprehensive Pneumology Center, Member of the German Center for Lung Research, 81377 Munich, Germany.
Birte KonradInstitute for Lung Biology and Disease, Ludwig-Maximilians University Hospital Munich, Asklepios Clinic Gauting and Helmholtz Zentrum München, Comprehensive Pneumology Center Munich, Max-Lebsche-Platz 31, 81377 Munich, Germany.
Kathrin MutzeHelmholtz Zentrum Munich, Lung Repair and Regeneration, Comprehensive Pneumology Center, Member of the German Center for Lung Research, 81377 Munich, Germany.ORCID 0000-0002-5577-4500
Oliver EickelbergDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA.ORCID 0000-0001-7170-0360
Melanie KönigshoffHelmholtz Zentrum Munich, Lung Repair and Regeneration, Comprehensive Pneumology Center, Member of the German Center for Lung Research, 81377 Munich, Germany.
Susanne Krauss-EtschmannEarly Life Origins of Chronic Lung Disease, Research Center Borstel, Leibniz Lung Center, Member of the German Center for Lung Research (DZL) and the Airway Research Center North (ARCN), 23845 Borstel, Germany.
German Center for Lung Research · DEHelmholtz Zentrum München · DEChristian-Albrechts-Universität zu Kiel · DEResearch Center Borstel - Leibniz Lung Center · DEUniversity of Pittsburgh Medical Center · US

Funding

Extracellular matrix composition and crosslinking patterns determine resident cell function in lung fibrosisR01HL146519 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EICKELBERG, OLIVER · 2020 to 2023
$2.5M
Non-canonical WNT signaling in emphysema and lung regenerationR01HL141380 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOENIGSHOFF, MELANIE · 2019 to 2022
$2.1M
NHLBI NIH HHS R01 HL141380NHLBI NIH HHS R01 HL146519
6 · The paper itself

Abstract

Alveolar type II (ATII) cells are essential for the maintenance of the alveolar homeostasis. However, knowledge of the expression of the miRNAs and miRNA-regulated networks which control homeostasis and coordinate diverse functions of murine ATII cells is limited. Therefore, we asked how miRNAs expressed in ATII cells might contribute to the regulation of signaling pathways. We purified "untouched by antibodies" ATII cells using a flow cytometric sorting method with a highly autofluorescent population of lung cells. TaqMan

Indexed as

Alveolar Epithelial CellsMicroRNAsAnimalsEpithelial-Mesenchymal TransitionHumansLungMiceRNA, MessengerMicroRNAsRNA, MessengerAECIIalveolar epithelial type II cellsATIIautofluorescenceEMTflow cytometryhomeostasismiRNAspathway analysisTGF-betatype II pneumocytes

Identifiers

PMID36011331
PMCPMC9407429
OpenAlexW4290989471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.