Evidence map›Paper›PMID 36011313›Full record

ArticleGenes2022

The Methylation of the p53 Targets the Genes

Elena N Voropaeva, Tatjana I Pospelova, Yuriy L Orlov, Maria I Churkina, Olga V Berezina, Anna A Gurazheva, Tatjana A Ageeva, Olga B Seregina, Vladimir N Maksimov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Medical Genetics, Genomics and Bioinformatics-2022.International journal of molecular sciences · 2023
    Article
  5. Research Topics of the Bioinformatics of Gene Regulation.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Elena N VoropaevaResearch Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, 630089 Novosibirsk, Russia.ORCID 0000-0001-7542-7285
Tatjana I PospelovaFaculty of Advanced Training and Retraining of Doctors, Novosibirsk State Medical University of the Ministry of Health of the Russian Federation, 630091 Novosibirsk, Russia.
Yuriy L OrlovResearch Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, 630089 Novosibirsk, Russia.ORCID 0000-0003-0587-1609
Maria I ChurkinaFaculty of Advanced Training and Retraining of Doctors, Novosibirsk State Medical University of the Ministry of Health of the Russian Federation, 630091 Novosibirsk, Russia.
Olga V BerezinaFaculty of Advanced Training and Retraining of Doctors, Novosibirsk State Medical University of the Ministry of Health of the Russian Federation, 630091 Novosibirsk, Russia.
Anna A GurazhevaResearch Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, 630089 Novosibirsk, Russia.
Tatjana A AgeevaFaculty of Advanced Training and Retraining of Doctors, Novosibirsk State Medical University of the Ministry of Health of the Russian Federation, 630091 Novosibirsk, Russia.
Olga B SereginaFaculty of Advanced Training and Retraining of Doctors, Novosibirsk State Medical University of the Ministry of Health of the Russian Federation, 630091 Novosibirsk, Russia.
Vladimir N MaksimovResearch Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, 630089 Novosibirsk, Russia.
Novosibirsk State Medical University · RUInstitute of Cytology and Genetics · RUSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulation of oncogenes by microRNA is a focus of medical research. hsa-miR-203, hsa-mir-129, hsa-miR-34a, hsa-miR-34b and hsa-miR-34c are oncosuppressive microRNAs that mediate the antitumor activity of p53. We seek to evaluate the frequencies, co-occurrence and clinical significance of the methylation of the

Indexed as

Lymphoma, Large B-Cell, DiffuseMicroRNAsDNA MethylationGene Expression Regulation, NeoplasticHumansTumor Suppressor Protein p53MicroRNAsMirn129 microRNA, humanMIRN203 microRNA, humanTumor Suppressor Protein p53diffuse large B-cell lymphomamethylationmicroRNA

Identifiers

PMID36011313
PMCPMC9408007
OpenAlexW4290600851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.