Evidence map›Paper›PMID 36011015›Full record

ReviewCancers2022

Next Steps for Immunotherapy in Glioblastoma.

Toni Q Cao, Derek A Wainwright, Catalina Lee-Chang, Jason Miska, Adam M Sonabend, Amy B Heimberger, Rimas V Lukas

Abstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Current approaches in glioblastoma multiforme immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Toni Q CaoDepartment of Neurology, Northwestern University, Chicago, IL 60611, USA.
Derek A WainwrightDepartment of Neurological Surgery, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-7232-4264
Catalina Lee-ChangDepartment of Neurological Surgery, Northwestern University, Chicago, IL 60611, USA.
Jason MiskaDepartment of Neurological Surgery, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-9608-2810
Adam M SonabendDepartment of Neurological Surgery, Northwestern University, Chicago, IL 60611, USA.
Amy B HeimbergerDepartment of Neurological Surgery, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-9970-8695
Rimas V LukasDepartment of Neurology, Northwestern University, Chicago, IL 60611, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
STINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBMP50CA221747 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hui Zhang · 2018 to 2026
$21.4M
Modulation of Microglia and T Cell Interactions in Malignant GliomaR01CA120813 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIMBERGER, AMY BETH, RAO, GANESH · 2007 to 2025
$4.7M
IDO1 and Immunotolerance in GlioblastomaR01NS097851 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHILTZ, GARY E, WAINWRIGHT, DEREK ALAN · 2016 to 2025
$4.6M
MAPK as target of glioma immunoediting by CD8 T-cells, and predictor of response to immunotherapyR01NS110703 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SONABEND, ADAM M · 2020 to 2024
$1.9M
Stinging the Glioma Immune LandscapeR01NS120547 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIMBERGER, AMY BETH, RAO, ARVIND · 2020 to 2023
$1.1M
The interaction of IDO and Tregs Leads to Immunosuppression in GliomaR00NS082381 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAINWRIGHT, DEREK ALAN · 2014 to 2016
$735k
Aging, immunosenescence and glioblastomaK02AG068617 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAINWRIGHT, DEREK ALAN · 2020 to 2024
$688k
The interaction of IDO and Tregs Leads to Immunosuppression in GliomaK99NS082381 · NINDS · UNIVERSITY OF CHICAGO · PI WAINWRIGHT, DEREK ALAN · 2013 to 2014
$173k
The role of IDO and Th17 in an experimental mouse model of gliomaF32NS073366 · NINDS · UNIVERSITY OF CHICAGO · PI WAINWRIGHT, DEREK ALAN · 2011 to 2012
$86k
NCI NIH HHS CA120813NCI NIH HHS P30 CA060553NCI NIH HHS P30CA060553NCI NIH HHS P50 CA221747NCI NIH HHS P50CA221747NCI NIH HHS R01 CA120813NIA NIH HHS K02 AG068617NINDS NIH HHS F32 NS073366NINDS NIH HHS K99 NS082381NINDS NIH HHS NS110703NINDS NIH HHS NS120547NINDS NIH HHS R00 NS082381NINDS NIH HHS R01 NS097851NINDS NIH HHS R01 NS110703NINDS NIH HHS R01 NS120547
6 · The paper itself

Abstract

Outcomes for glioblastoma (GBM) patients undergoing standard of care treatment remain poor. Here we discuss the portfolio of previously investigated immunotherapies for glioblastoma, including vaccine therapy and checkpoint inhibitors, as well as novel emerging therapeutic approaches. In addition, we explore the factors that potentially influence response to immunotherapy, which should be considered in future research aimed at improving immunotherapy efficacy.

Indexed as

glioblastomaimmune systemimmunotherapy

Identifiers

PMID36011015
PMCPMC9406905

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.