Evidence map›Paper›PMID 36010927›Full record

ArticleCancers2022

Treatment Outcomes of Computer Tomography-Guided Brachytherapy in Cervical Cancer in Hong Kong: A Retrospective Review.

Wing-Lok Chan, Matthew Ho-Fai Cheng, Jacky Tsun-Kit Wu, Cheuk-Wai Choi, Rosa Piu-Ying Tse, Patty Piu-Ying Ho, Emina Edith Cheung, Andy Cheung, Ka-Yu Test, Karen Kar-Loen Chan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Wing-Lok ChanDepartment of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID 0000-0001-9793-9273
Matthew Ho-Fai ChengLKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID 0000-0003-3058-4265
Jacky Tsun-Kit WuLKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Cheuk-Wai ChoiSchool of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Rosa Piu-Ying TseDepartment of Clinical Oncology, Queen Mary Hospital, Hong Kong, China.
Patty Piu-Ying HoDepartment of Clinical Oncology, Queen Mary Hospital, Hong Kong, China.
Emina Edith CheungDepartment of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Andy CheungDepartment of Clinical Oncology, Queen Mary Hospital, Hong Kong, China.
Ka-Yu TestDepartment of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID 0000-0001-8330-0970
Karen Kar-Loen ChanDepartment of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID 0000-0002-4034-7469
Hexane Yuen-Sheung NganDepartment of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Steven Wai-Kwan SiuDepartment of Clinical Oncology, Queen Mary Hospital, Hong Kong, China.
Roger Kai-Cheong NganDepartment of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Anne Wing-Mui LeeDepartment of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
University of Hong Kong · HKQueen Mary Hospital · CNUniversity of Hong Kong - Shenzhen Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: To report the long-term clinical outcomes of computer-tomography (CT)-guided brachytherapy (BT) for locally advanced cervical cancer. (2) Methods: A total of 135 patients with FIGO stage IB-IVA cervical cancer treated with definitive radiotherapy +/- chemotherapy with an IGABT boost at Queen Mary Hospital, Hong Kong, between November 2013 and December 2019 were included. Treatment included pelvic radiotherapy 40 Gy/20 Fr/4 weeks +/- chemotherapy then CT-guided BT (7 Gy × 4 Fr) and a sequential parametrial boost. The primary outcome was local control. Secondary outcomes were pelvic control, distant metastasis-free survival, overall survival (OS) and late toxicities. (3) Results: The median follow-up was 53.6 months (3.0-99.6 months). The five-year local control, pelvic control, distant metastasis-free survival and OS rates were 90.7%, 84.3%, 80.0% and 87.2%, respectively. The incidence of G3/4 long-term toxicities was 6.7%, including proctitis (2.2%), radiation cystitis (1.5%), bowel perforation (0.7%), ureteric stricture (0.7%) and vaginal stenosis and fistula (0.7%). Patients with adenocarcinomas had worse local control (HR 5.82, 95% CI 1.84-18.34,

Indexed as

adenocarcinomacervical cancercomputer tomographyimage-guided brachytherapylocal controllong-term outcomesurvival

Identifiers

PMID36010927
PMCPMC9406104
OpenAlexW4291743985

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.