Evidence map›Paper›PMID 36010874›Full record

ArticleCancers2022

Myofibroblastic CAF Density, Not Activated Stroma Index, Indicates Prognosis after Neoadjuvant Therapy of Pancreatic Carcinoma.

Ulrike Heger, Anna Martens, Lisa Schillings, Britta Walter, Domenic Hartmann, Ulf Hinz, Thomas Pausch, Nathalia Giese, Christoph W Michalski, Thilo Hackert

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Pancreatic cancer-associated myofibroblasts: a review.International journal of biological sciences · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ulrike HegerDepartment of General Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Anna MartensDepartment of General Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Lisa SchillingsDepartment of General Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Britta WalterDr. Senckenberg Institute of Pathology, Goethe University, 60590 Frankfurt, Germany.
Domenic HartmannDepartment of General Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Ulf HinzDepartment of General Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0001-8227-968X
Thomas PauschDepartment of General Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0001-6145-3263
Nathalia GieseDepartment of General Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Christoph W MichalskiDepartment of General Surgery, University Hospital, 89081 Ulm, Germany.
Thilo HackertDepartment of General Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Heidelberg University · DEGerman Cancer Research Center · DEGoethe University Frankfurt · DEUniversity Hospital Ulm · DE

Funding

Heidelberger Stiftung Chirurgie D.10053139
6 · The paper itself

Abstract

Neoadjuvant therapy (NT) for advanced PDAC is an emerging concept, affecting both stroma and tumor. The Activated Stroma Index (ASI; ratio of activated cancer-associated fibroblasts (CAF) to collagen deposition) is a prognostic marker in upfront resected pancreatic adenocarcinoma (PDAC). We assessed ASI and its prognostic relevance after NT. Tissue from resection specimens of

Indexed as

CAFcollagenFOLFIRINOXneoadjuvant therapypaclitaxelpancreatic cancertumor stroma

Identifiers

PMID36010874
PMCPMC9406210
OpenAlexW4291011425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.