Evidence map›Paper›PMID 36010647›Full record

ReviewCells2022

Rare Inherited Cholestatic Disorders and Molecular Links to Hepatocarcinogenesis.

Rebecca Jeyaraj, Deirdre Kelly

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rebecca JeyarajNational Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London, London WC1N 1EH, UK.
Deirdre KellyInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0001-9776-4354
Birmingham Women's Hospital · GBGreat Ormond Street Hospital · GB

Funding

Department of Health
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver cancer affecting adults and the second most common primary liver cancer affecting children. Recent years have seen a significant increase in our understanding of the molecular changes associated with HCC. However, HCC is a complex disease, and its molecular pathogenesis, which likely varies by aetiology, remains to be fully elucidated. Interestingly, some inherited cholestatic disorders that manifest in childhood are associated with early HCC development. This review will thus explore how three genes that are associated with liver disease in childhood (

Indexed as

Carcinoma, HepatocellularCholestasisLiver NeoplasmsAdultCarcinogenesisChildHumansVesicular Transport ProteinsVesicular Transport ProteinsVPS33B protein, humanABCB11 genehepatocarcinogenesishepatocellular carcinomainherited cholestasisTJP2 geneVPS33B gene

Identifiers

PMID36010647
PMCPMC9406938
OpenAlexW4293778025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.