Evidence map›Paper›PMID 36010592›Full record

ArticleCells2022

p73α1, an Isoform of the p73 Tumor Suppressor, Modulates Lipid Metabolism and Cancer Cell Growth via Stearoyl-CoA Desaturase-1.

Zachary Rabow, Kyra Laubach, Xiangmudong Kong, Tong Shen, Shakur Mohibi, Jin Zhang, Oliver Fiehn, Xinbin Chen

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zachary RabowWest Coast Metabolomics Center, University of California, Davis, CA 95616, USA.ORCID 0000-0001-6213-4950
Kyra LaubachComparative Oncology Laboratory, Schools of Medicine and Veterinary Medicine, University of California, Davis, CA 95616, USA.
Xiangmudong KongComparative Oncology Laboratory, Schools of Medicine and Veterinary Medicine, University of California, Davis, CA 95616, USA.
Tong ShenWest Coast Metabolomics Center, University of California, Davis, CA 95616, USA.ORCID 0000-0002-6091-8783
Shakur MohibiComparative Oncology Laboratory, Schools of Medicine and Veterinary Medicine, University of California, Davis, CA 95616, USA.ORCID 0000-0001-5539-0841
Jin ZhangComparative Oncology Laboratory, Schools of Medicine and Veterinary Medicine, University of California, Davis, CA 95616, USA.
Oliver FiehnWest Coast Metabolomics Center, University of California, Davis, CA 95616, USA.ORCID 0000-0002-6261-8928
Xinbin ChenComparative Oncology Laboratory, Schools of Medicine and Veterinary Medicine, University of California, Davis, CA 95616, USA.ORCID 0000-0002-4582-6506
University of California, Davis · US

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI FRED H GAGE · 2004 to 2026
$102.6M
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
TRAINING IN COMPARATIVE LUNG BIOLOGY AND MEDICINET32HL007013 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI Elena Goncharova, Nicholas J. KENYON · 1985 to 2026
$10.1M
MECHANISM OF P73 DEPENDENT TUMOR SUPPRESSIONR01CA081237 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 1999 to 2022
$6.8M
NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA081237NHLBI NIH HHS T32 HL007013NIA NIH HHS P30 AG072972NIA NIH HHS U19 AG023122
6 · The paper itself

Abstract

Altered lipid metabolism is a hallmark of cancer. p73, a p53 family member, regulates cellular processes and is expressed as multiple isoforms. However, the role of p73 in regulating lipid metabolism is not well-characterized. Previously, we found that loss of p73 exon 12 (

Indexed as

Lipid MetabolismNeoplasmsFatty AcidsFatty Acids, MonounsaturatedPhosphatidylcholinesProtein IsoformsStearoyl-CoA DesaturaseFatty AcidsFatty Acids, MonounsaturatedPhosphatidylcholinesProtein IsoformsStearoyl-CoA DesaturaseKennedy pathwaylipid metabolismp73 isoformsStearoyl-CoA Desaturasethe p53 family

Identifiers

PMID36010592
PMCPMC9406568
OpenAlexW4291366699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.