Evidence map›Paper›PMID 36010543›Full record

ArticleCells2022

Noura N Ballasy, Elizabeth A Bering, Caroline Kokorudz, Bethany N Radford, Xiang Zhao, Wendy Dean, Myriam Hemberger

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Transcriptomic analysis of PADI4 target genes during multi-lineage differentiation of embryonic stem cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  7. Co-expression of PADI isoforms during progenitor differentiation enables functional diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Noura N BallasyDepartment of Biochemistry and Molecular Biology, Cumming School of Medicine, 3330 Hospital Drive NW, University of Calgary, Calgary, AB T2N 4N1, Canada.
Elizabeth A BeringDepartment of Biochemistry and Molecular Biology, Cumming School of Medicine, 3330 Hospital Drive NW, University of Calgary, Calgary, AB T2N 4N1, Canada.
Caroline KokorudzDepartment of Biochemistry and Molecular Biology, Cumming School of Medicine, 3330 Hospital Drive NW, University of Calgary, Calgary, AB T2N 4N1, Canada.
Bethany N RadfordDepartment of Biochemistry and Molecular Biology, Cumming School of Medicine, 3330 Hospital Drive NW, University of Calgary, Calgary, AB T2N 4N1, Canada.
Xiang ZhaoDepartment of Cell Biology and Anatomy, Cumming School of Medicine, 3330 Hospital Drive NW, University of Calgary, Calgary, AB T2N 4N1, Canada.
Wendy DeanDepartment of Cell Biology and Anatomy, Cumming School of Medicine, 3330 Hospital Drive NW, University of Calgary, Calgary, AB T2N 4N1, Canada.ORCID 0000-0001-9441-5044
Myriam HembergerDepartment of Biochemistry and Molecular Biology, Cumming School of Medicine, 3330 Hospital Drive NW, University of Calgary, Calgary, AB T2N 4N1, Canada.ORCID 0000-0003-3332-6958
University of Calgary · CA

Funding

Biotechnology and Biological Sciences Research Council BB/S002995/1CIHR RN435448–450828
6 · The paper itself

Abstract

Histone citrullination is a relatively poorly studied epigenetic modification that involves the irreversible conversion of arginine residues into citrulline. It is conferred by a small family of enzymes known as protein arginine deiminases (PADIs). PADI function supports the pluripotent state of embryonic stem cells, but in other contexts, also promotes efficient cellular differentiation. In the current study, we sought to gain deeper insights into the possible roles of PADIs in mouse trophoblast stem cells (TSCs). We show that

Indexed as

EpigenomicsMouse Embryonic Stem CellsTrophoblastsAnimalsCell DifferentiationMiceProtein-Arginine DeiminasesProtein-Arginine Deiminase Type 2Protein-Arginine Deiminase Type 3PAD3 protein, mousePadi2 protein, mouseProtein-Arginine DeiminasesProtein-Arginine Deiminase Type 2Protein-Arginine Deiminase Type 3DNA methylationepigenetic regulationhistone citrullinationPADItrophoblast giant cellstrophoblast stem cells

Identifiers

PMID36010543
PMCPMC9406452
OpenAlexW4293514958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.