ArticleDiagnostics (Basel, Switzerland)2022
Cell Toxicity Study of Antiseptic Solutions Containing Povidone-Iodine and Hydrogen Peroxide.
Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Systemic iodine levels increase with povidone-iodine irrigation, but does this affect thyroid functions? A case-control study.Journal of orthopaedic surgery and research · 2024Trial
- Tactical use of irrigants in open orthopaedic procedures: 'what to use & when'.EFORT open reviews · 2026Review
- Iodine-Based Wound Dressing Versus Antibiotic Therapy for Postoperative Symptom Relief in Third Molar Surgery.Cureus · 2026Article
- Use of a Novel Surgical Irrigant Significantly Reduces Rate of Infection in Primary Hip and Knee Arthroplasty at 1 year.Arthroplasty today · 2025Article
- Effect of Antiseptic Irrigation Solutions on Primary Human Knee Fibroblasts Cultured in Human Platelet Lysate.The Journal of arthroplasty · 2025Article
- Efficacy of Different Irrigation Solutions on Bacterial Biofilm in Periprosthetic Joint Infections: A Systematic Review and Network Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- The paradoxical activity of BRAF inhibitors: potential use in wound healing.Archives of dermatological research · 2025Review
- Does a Specific Sequential Combination of Antiseptic Solutions for Chemical Debridement in Periprosthetic Joint Infection Improve Outcomes vs. Solution Alone? An In Vivo Study.Antibiotics (Basel, Switzerland) · 2024Article
- Assessing the Effects of Surgical Irrigation Solutions on Human Neutrophil Interactions with NascentMicroorganisms · 2024Article
- Antiseptics' Concentration, Combination, and Exposure Time on Bacterial and Fungal Biofilm Eradication.Arthroplasty today · 2024Article
- Tolerability of N-chlorotaurine in comparison with routinely used antiseptics: an in vitro study on chondrocytes.Pharmacological reports : PR · 2024Article
- Engineering Nitric Oxide-Releasing Antimicrobial Dental Coating for Targeted Gingival Therapy.ACS applied bio materials · 2024Article
- The Effect of Spacer Treatment of Infected Hip and Knee Arthroplasties on Patients' Mental Health: A Narrative Review of the Literature.Healthcare (Basel, Switzerland) · 2024Review
- In-vivo and in-vitro wound healing and tissue repair effect of Trametes versicolor polysaccharide extract.Scientific reports · 2024Article
- Histopathological and histomorphometric investigation of the effects of different irrigation solutions on Achilles tendon healing in rats.Joint diseases and related surgery · 2024Article
- Effective degradation of various bacterial toxins using ozone ultrafine bubble water.PloS one · 2024Article
- An In Vitro Study to Assess the Best Strategy for the Chemical Debridement of Periprosthetic Joint Infection.Antibiotics (Basel, Switzerland) · 2023Article
- Topical Probiotic Formulation Promotes Rapid Healing in Dog Keratinocyte Cells: A Promising Approach for Wound Management.International journal of molecular sciences · 2023Article
- Germicidal potential and skin compatibility of an innovative UVC phototherapy device emitting at 234 nm.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing incidence of periprosthetic joint infections (PJIs) has led to a growing interest in developing strategies to prevent and treat this severe complication. The surgical site's application of antiseptic solutions to eliminate contaminating bacteria and eradicate the bacterial biofilm has been increasing over time. Even though it has been proven that combining antimicrobials could enhance their activities and help overcome acquired microbial resistance related to the topical use of antibiotics, the toxicity of integrated solutions is not well described. This study aimed to evaluate the cytotoxicity of solutions containing povidone-iodine (PI) and hydrogen peroxide (H2O2), alone or in combination, after 1.3 and 5 min of exposure. Chondrocytes, tenocytes, and fibroblast-like synoviocytes were used for cytotoxicity analysis. Trypan blue stain (0.4% in PBS) was applied to evaluate the dead cells. All solutions tested showed a progressive increase in toxicity as exposure time increased except for PI at 0.3%, which exhibited the lowest toxicity. The combined solutions reported a reduced cellular killing at 3 and 5 min than H2O2 at equal concentrations, similar results to PI solutions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.