ArticleAntibiotics (Basel, Switzerland)2022
Control of Healthcare-Associated Carbapenem-Resistant
Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Can machine learning support infection control measures by predicting carbapenemase-producing Enterobacterales colonization at admission?Infection control and hospital epidemiology · 2026Article
- Comparative genomic insights into carbapenem-resistant versus susceptibleFrontiers in cellular and infection microbiology · 2026Article
- Impact of Enhanced Infection Control Measures on Hospital-Acquired Carbapenem-ResistantInfection and drug resistance · 2026Article
- Observational
- A retrospective analysis of pathogen distribution and antimicrobial resistance trends of bacteria in a tertiary hospital in China, 2021-2025.Frontiers in cellular and infection microbiology · 2026Article
- Does a multimodal educational intervention involving pre-intern 'hand hygiene covert observers' improve hand hygiene compliance among medical interns?Antimicrobial resistance and infection control · 2025Article
- Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2025Review
- Comparative Evaluation and Performance of Large Language Models in Clinical Infection Control Scenarios: A Benchmark Study.Healthcare (Basel, Switzerland) · 2025Article
- Promoting hand hygiene in a chemotherapy day center: the role of a robot.Antimicrobial resistance and infection control · 2024Observational
- A Systematic Review and Meta-Analysis of Molecular Characteristics on Colistin Resistance ofDiagnostics (Basel, Switzerland) · 2024Review
- Epidemiological and Clinical Insights intoInternational journal of general medicine · 2024Article
- The Emergence ofInfection and drug resistance · 2024Article
- S2k-Guideline hand antisepsis and hand hygiene.GMS hygiene and infection control · 2024Article
- Epidemiology of multidrug-resistant organisms before and during COVID-19 in Hong Kong.Infection prevention in practice · 2023Article
- Colistin Resistance inAntibiotics (Basel, Switzerland) · 2023Review
- Infection of healthcare workers despite a high vaccination rate during the fifth wave of COVID-19 due to Omicron variant in Hong Kong.Infection prevention in practice · 2023Article
- Gastrointestinal Colonization of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2022Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Antimicrobial stewardship and infection control measures are equally important in the control of antimicrobial-resistant organisms. We conducted a retrospective analysis of the incidence rate of hospital-onset carbapenem-resistant Acinetobacter baumannii (CRAB) infection (per 1000 patient days) in the Queen Mary Hospital, a 1700-bed, university-affiliated teaching hospital, from period 1 (1 January 2007 to 31 December 2013) to period 2 (1 January 2014 to 31 December 2019), where enhanced infection control measures, including directly observed hand hygiene before meal and medication rounds to conscious patients, and the priority use of single room isolation, were implemented during period 2. This study aimed to investigate the association between enhanced infection control measures and changes in the trend in the incidence rate of hospital-onset CRAB infection. Antimicrobial consumption (defined daily dose per 1000 patient days) was monitored. Interrupted time series, in particular segmented Poisson regression, was used. The hospital-onset CRAB infection increased by 21.3% per year [relative risk (RR): 1.213, 95% confidence interval (CI): 1.162−1.266, p < 0.001], whereas the consumption of the extended spectrum betalactam-betalactamase inhibitor (BLBI) combination and cephalosporins increased by 11.2% per year (RR: 1.112, 95% CI: 1.102−1.122, p < 0.001) and 4.2% per year (RR: 1.042, 95% CI: 1.028−1.056, p < 0.001), respectively, in period 1. With enhanced infection control measures, the hospital-onset CRAB infection decreased by 9.8% per year (RR: 0.902, 95% CI: 0.854−0.953, p < 0.001), whereas the consumption of the extended spectrum BLBI combination and cephalosporins increased by 3.8% per year (RR: 1.038, 95% CI: 1.033−1.044, p < 0.001) and 7.6% per year (RR: 1.076, 95% CI: 1.056−1.097, p < 0.001), respectively, in period 2. The consumption of carbapenems increased by 8.4% per year (RR: 1.84, 95% CI: 1.073−1.094, p < 0.001) in both period 1 and period 2. The control of healthcare-associated CRAB could be achieved by infection control measures with an emphasis on directly observed hand hygiene, despite an increasing trend of antimicrobial consumption.
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