Evidence map›Paper›PMID 36009885›Full record

ReviewAntibiotics (Basel, Switzerland)2022

Is It Possible to Eradicate Carbapenem-Resistant

Filippo Medioli, Erica Bacca, Matteo Faltoni, Giulia Jole Burastero, Sara Volpi, Marianna Menozzi, Gabriella Orlando, Andrea Bedini, Erica Franceschini, Cristina Mussini and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Comparative genomic insights into carbapenem-resistant versus susceptibleFrontiers in cellular and infection microbiology · 2026
    Article
  4. Update on infection prevention in the ICU.Current opinion in critical care · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Molecular Epidemiology of Clinical Carbapenem-ResistantTropical medicine and infectious disease · 2022
    Article
  15. Gastrointestinal Colonization of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2022
    Article
  16. Carbapenem-resistantJournal of research in pharmacy practice
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Filippo MedioliDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy.
Erica BaccaDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy.ORCID 0000-0001-7164-5293
Matteo FaltoniDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy.
Giulia Jole BurasteroDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy.
Sara VolpiDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy.
Marianna MenozziDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy.
Gabriella OrlandoDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy.ORCID 0000-0002-4590-9045
Andrea BediniDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy.ORCID 0000-0002-4041-1459
Erica FranceschiniDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy.ORCID 0000-0001-6922-5759
Cristina MussiniClinic of Infectious Diseases, Department of Infectious Diseases, University of Modena, 41124 Modena, Italy.
Marianna MeschiariDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy.ORCID 0000-0002-1254-9995
Azienda Ospedaliero-Universitaria di Modena · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the global efforts to antagonize carbapenem-resistant

methodsThe study was a critical review of the literature aiming to evaluate all available studies reporting IPC measures to control CRAB in ICU and outside ICU in both epidemic and endemic settings in the past 10 years.

resultsAmong the 12 included studies, the majority consisted of research reports of outbreaks mostly occurred in ICUs. The reported mortality reached 50%. Wide variability was observed related to the frequency of application of recommended CRAB IPC measures among the studies: environmental disinfection (100%); contact precautions (83%); cohorting staff and patients (75%); genotyping (66%); daily chlorhexidine baths (58%); active rectal screening (50%); closing or stopping admissions to the ward (33%).

conclusionsDespite effective control of CRAB spreading during the outbreaks, the IPC measures reported were heterogeneous and highly dependent on the different setting as well as on the structural characteristics of the wards. Reinforced 'search and destroy' strategies both on the environment and on the patient, proved to be the most effective measures for permanently eliminating CRAB spreading.

Indexed as

Acinetobacter baumanniiAcinetobacter baumannii carbapenemasecarbapenemasecarbapenem-resistantgram-negativeinfection controlinfection preventionintensive care unitsmulti-drug resistanceoutbreak

Identifiers

PMID36009885
PMCPMC9405503
OpenAlexW4288439444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.