Evidence map›Paper›PMID 36009791›Full record

ArticleBiology2022

From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms.

Liana Shvachiy, Ângela Amaro-Leal, Tiago F Outeiro, Isabel Rocha, Vera Geraldes

Open access · goldAbstract read
In one paragraph

Article in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Unravelling lead-induced toxicity in mammals: the role of oxidative stress and apoptosis and their modulation by emerging therapeutic strategies.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Liana ShvachiyDepartment of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37073 Göttingen, Germany.ORCID 0000-0002-4576-0017
Ângela Amaro-LealCardiovascular Centre of the University of Lisbon, 1649-028 Lisbon, Portugal.ORCID 0000-0001-7191-6372
Tiago F OuteiroDepartment of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37073 Göttingen, Germany.
Isabel RochaCardiovascular Centre of the University of Lisbon, 1649-028 Lisbon, Portugal.
Vera GeraldesCardiovascular Centre of the University of Lisbon, 1649-028 Lisbon, Portugal.
University of Lisbon · PTGerman Center for Neurodegenerative Diseases · DE

Funding

Deutsche Forschungsgemeinschaft 2067/1- 390729940Fundação para a Ciência e Tecnologia SFRH/BD/143286/2019Fundação para a Ciência e Tecnologia SFRH/BPD/119315/2016
6 · The paper itself

Abstract

Lead is a heavy metal whose widespread use has resulted in environmental contamination and significant health problems, particularly if the exposure occurs during developmental stages. It is a cumulative toxicant that affects multiple systems of the body, including the cardiovascular and nervous systems. Chronic lead exposure has been defined as a cause of behavioral changes, inflammation, hypertension, and autonomic dysfunction. However, different environmental lead exposure paradigms can occur, and the different effects of these have not been described in a broad comparative study. In the present study, rats of both sexes were exposed to water containing lead acetate (0.2%

Indexed as

baroreflex impairmentenvironmental lead exposurehypertensionlong-term memory impairment

Identifiers

PMID36009791
PMCPMC9405384
OpenAlexW4289705080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.