ArticleAnimals : an open access journal from MDPI2022
Effect of an Immunomodulatory Feed Additive in Mitigating the Stress Responses in Lactating Dairy Cows to a High Concentrate Diet Challenge.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Behavioural and health status assessment of cattle in a semi-intensive system.Tropical animal health and production · 2026Article
- Interaction Effects Between Tongue-Rolling Behavior and Chronic Stress on Plasma Immune-Inflammatory Indicators, Milk Protein Composition, and Milk Proteome in Dairy Cows.Veterinary sciences · 2026Article
- Current Understanding of Bovine Ketosis: From Molecular Basis to Farm-Level Management.Animals : an open access journal from MDPI · 2025Review
- Effect of a feed additive based on a mix of condense and hydrolysable tannins (ByProTropical animal health and production · 2025Article
- Complementary Effects of Essential Oils and Organic Acids on Rumen Physiology as Alternatives to Antibiotic Feed Additives.Animals : an open access journal from MDPI · 2025Review
- Body condition score at calving, subclinical ketosis, postpartum body condition score losses, diseases, and fertility in Holstein cows: modelling confounding associations.Veterinary and animal science · 2025Article
- Effect of a mix of condense and hydrolysable tannins feed additive on lactating dairy cows' services per conception and days open.Veterinary and animal science · 2025Article
- Wearable Collar Technologies for Dairy Cows: A Systematized Review of the Current Applications and Future Innovations in Precision Livestock Farming.Animals : an open access journal from MDPI · 2025Review
- Comparison between linear mixed model and threshold model in the estimation of variance components in age at first calving and milk production in buffaloes.Frontiers in veterinary science · 2025Article
- Animal health and nutrition: metabolic disorders in cattle and improvement strategies.Frontiers in veterinary science · 2025Review
- Precision monitoring of rumination and locomotion in relation to milk fat-to-protein ratio in early lactation dairy cattle.Frontiers in veterinary science · 2025Article
- The use of rumen-protected amino acids and fibrous by-products can increase the sustainability of milk production.Frontiers in veterinary science · 2025Article
- In vitro and in vivo analysis of rumen fermentation after supplementary niacin in high concentrated fed cattle.Tropical animal health and production · 2024Article
- Nutritional Strategies to Alleviate Stress and Improve Welfare in Dairy Ruminants.Animals : an open access journal from MDPI · 2024Review
- Effect of Adding Yeast Cultures to High-Grain Conditions on Production Performance, Rumen Fermentation Profile, Microbial Abundance, and Immunity in Goats.Animals : an open access journal from MDPI · 2024Article
- Effect of physically effective neutral detergent fiber on nutrient intake and digestibility, ruminal and blood parameters, and ingestive behavior of confined beef cattle.Tropical animal health and production · 2023Article
- Effects of a High-Concentrate Diet on the Blood Parameters and Liver Transcriptome of Goats.Animals : an open access journal from MDPI · 2023Article
- Effect of Dietary Organic Acids and Botanicals on Metabolic Status and Milk Parameters in Mid-Late Lactating Goats.Animals : an open access journal from MDPI · 2023Article
- Stayability in Simmental cattle as affected by muscularity and body condition score between calvings.Frontiers in veterinary science · 2023Article
- Effects of herbal supplements on milk production quality and specific blood parameters in heat-stressed early lactating cows.Frontiers in veterinary science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dairy cows are often exposed to multiple stressors in a lactation-cycle, with sub-acute ruminal acidosis (SARA) a frequent example of nutritional stress. SARA affects ruminal and intestinal equilibrium resulting in dysbiosis with localized and systemic inflammation impacting animal health and productivity. OmniGen-AF (OMN, Phibro Animal Health Corporation, Teaneck, NJ, USA) is a feed product recognized for modulating innate immune function, especially during periods of stress. The objective of this study was to determine the effects of OMN in lactating dairy cows fed a high-starch, low-fiber diet. Twenty-four blocked cows were assigned to control or treatment (55 g/d). After the additive adaptation (49 d) cows were fed the challenge diet (28 d). Milk, rumination and pH were continuously recorded; components, rumen fluid, and blood were taken in multiple time-point and analyzed. Results showed that the challenge decreased the rumination, shifted ruminal fluid composition, decreased milk production and the components, and slightly increased the time below pH 5.5, with no differences between groups. The treatment produced greater rumen butyrate and lower lactate, prompter regeneration of red blood cells, increase of neutrophils, lower paraoxonase, gamma-glutamyl-transferase, and β-hydroxybutyrate, with no differences on other tested inflammatory markers. Results show that OMN helps modulating some of the metabolic and immunological responses to SARA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.