ArticleAnimals : an open access journal from MDPI2022
Effect of a Single and Triple Dose of Levamisole on Hematological Parameters in Controlled Inflammation Model.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- In silico and in vivo assessment of the immunostimulatory activity of palmitic acid derived from Vernonia amygdalina.Scientific reports · 2025Article
- Single‑dose levamisole at breeding alters early pregnancy immune-endocrine profiles without affecting fertility in ewes.BMC veterinary research · 2025Article
- Comparing the toxicity of selected plant extract anthelmintics to levamisole hydrochloride and piperazine citrate in chickens.The Onderstepoort journal of veterinary research · 2025Article
- Repositioning anthelmintics for the treatment of inflammatory-based pathological conditions.Inflammopharmacology · 2025Review
- Levamisole Ameliorates Rheumatoid Arthritis by Downregulating the PI3K/Akt Pathway in SD Rats.Pharmaceuticals (Basel, Switzerland) · 2024Article
- The Effectiveness of Levamisole and Broccoli in Lead Poisoning: Hematobiochemical Changes and Tissue Damage in the Liver, Kidney, and Spleen of Wistar Rats.Journal of toxicology · 2024Article
- Safety Evaluation of a Potential Anti-Rheumatoid Arthritis Candidate, Levamisole.Journal of inflammation research · 2024Article
- Effectiveness of oral levamisole as an adjuvant to hepatitis B vaccination in healthcare workers non-responsive to previous vaccination: A randomized controlled trial.New microbes and new infections · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the impact of single and triple administration of levamisole on the dynamics of hematological parameters during experimental pleuritis. The experiment was performed on female Buffalo rats. Rats were randomly assigned to two equal groups that received 1 and 3 doses of levamisole every 2, 24 and 48 h, respectively. Following the experiment, blood samples for the measurement of hematological parameters were collected. The study group receiving three doses of levamisole observed a significant reduction of red blood cell count at 48 h post administration and an increase in mean corpuscular volume compared to the control inflammation group. The administration of a single dose of levamisole results in a significant increase in hematocrit at 72 h, an increase in white blood cell count at 24 h and 72 h, and an increase in neutrophil count at 72 h compared to the control inflammation group. Administration of a single and triple dose of levamisole showed statistically significant modification of some hematological parameters and thus modulates the inflammatory process. In the lungs, this results in a reduction in leukocyte infiltrations around the bronchi and blood vessels.
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Registered trials
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