Evidence map›Paper›PMID 36009635›Full record

ArticleAnimals : an open access journal from MDPI2022

Intestinal S100/Calgranulin Expression in Cats with Chronic Inflammatory Enteropathy and Intestinal Lymphoma.

Denise S Riggers, Corinne Gurtner, Martina Protschka, Denny Böttcher, Wolf von Bomhard, Gottfried Alber, Karsten Winter, Joerg M Steiner, Romy M Heilmann

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Fecal S100A12 concentrations in cats with chronic enteropathies.Journal of feline medicine and surgery · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Denise S RiggersSmall Animals Department, College of Veterinary Medicine, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0002-5160-9735
Corinne GurtnerInstitute of Animal Pathology, Department of Infectious Diseases and Pathobiology (DIP), Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
Martina ProtschkaInstitute of Immunology/Molecular Pathogenesis, Center for Biotechnology and Biomedicine, College of Veterinary Medicine, Leipzig University, 04103 Leipzig, Germany.
Denny BöttcherInstitute of Veterinary Pathology, College of Veterinary Medicine, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0001-8986-4873
Wolf von BomhardVeterinary Pathology Center, 80689 Munich, Germany.
Gottfried AlberInstitute of Immunology/Molecular Pathogenesis, Center for Biotechnology and Biomedicine, College of Veterinary Medicine, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0001-7475-4858
Karsten WinterInstitute of Anatomy, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.
Joerg M SteinerGastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Romy M HeilmannSmall Animals Department, College of Veterinary Medicine, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0003-3485-5157
Leipzig University · DETexas A&M University · USUniversity of Bern · CH

Funding

EveryCat Health Foundation W21-030
6 · The paper itself

Abstract

Diagnosing chronic inflammatory enteropathies (CIE) in cats and differentiation from intestinal lymphoma (IL) using currently available diagnostics is challenging. Intestinally expressed S100/calgranulins, measured in fecal samples, appear to be useful non-invasive biomarkers for canine CIE but have not been evaluated in cats. We hypothesized S100/calgranulins to play a role in the pathogenesis of feline chronic enteropathies (FCE) and to correlate with clinical and/or histologic disease severity. This retrospective case-control study included patient data and gastrointestinal (GI) tissues from 16 cats with CIE, 8 cats with IL, and 16 controls with no clinical signs of GI disease. GI tissue biopsies were immunohistochemically stained using polyclonal α-S100A8/A9 and α-S100A12 antibodies. S100A8/A9

Indexed as

calgranulin Ccalgranulinscalprotectinchronic enteropathychronic inflammatory enteropathyfelinefood-responsive enteropathyintestinal lymphomaS100A12S100A8/A9small-cell lymphoma

Identifiers

PMID36009635
PMCPMC9404432
OpenAlexW4291011684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.