Evidence map›Paper›PMID 36009523›Full record

ArticleBiomedicines2022

Defect of IL17 Signaling, but Not Centrinone, Inhibits the Development of Psoriasis and Skin Papilloma in Mouse Models.

Ben Jin, Yongfeng Zhang, Haiyan D Miller, Ling He, Dongxia Ge, Alun R Wang, Zongbing You

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ben JinSoutheast Louisiana Veterans Health Care System, New Orleans, LA 70119, USA.
Yongfeng ZhangDepartment of Structural & Cellular Biology, Tulane University, New Orleans, LA 70112, USA.
Haiyan D MillerSoutheast Louisiana Veterans Health Care System, New Orleans, LA 70119, USA.
Ling HeDepartment of Structural & Cellular Biology, Tulane University, New Orleans, LA 70112, USA.
Dongxia GeDepartment of Structural & Cellular Biology, Tulane University, New Orleans, LA 70112, USA.
Alun R WangDepartment of Pathology and Laboratory Medicine, Tulane University, New Orleans, LA 70112, USA.
Zongbing YouSoutheast Louisiana Veterans Health Care System, New Orleans, LA 70119, USA.ORCID 0000-0001-5048-2229
Tulane University · US

Funding

The role of IL-17 in obesity-associated prostate cancer progressionI01BX004158 · VA · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · PI YOU, ZONGBING · 2019 to 2023
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BLRD VA I01 BX004158United States Department of Veterans Affairs I01BX004158
6 · The paper itself

Abstract

Patients with psoriasis tend to develop skin cancer, and the hyperproliferation of the epidermis is a histopathological hallmark of both psoriasis and cutaneous squamous cell carcinoma (SCC), indicating that they may share pathogenic mechanisms. Interleukin-17 (IL17) stimulates the proliferation of the epidermis, leading to psoriasis. Overexpression of Polo-like kinase 4 (PLK4), which controls centriole duplication, has been identified in SCC, which also shows the hyperproliferation of keratinocytes. To investigate the cooperation between IL17 signaling and centriole duplication in epidermal proliferation, we established psoriasis and skin papilloma models in wild type (WT), IL17 receptor A (T779A) knockin (

Indexed as

centrinoneIL17RAIL17RCpsoriasisskin papilloma

Identifiers

PMID36009523
PMCPMC9405709
OpenAlexW4291743201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.