Evidence map›Paper›PMID 36009502›Full record

ArticleBiomedicines2022

Association of N-Acetyl Asparagine with QTc in Diabetes: A Metabolomics Study.

Giacomo Gravina, Melissa Y Y Moey, Edi Prifti, Farid Ichou, Olivier Bourron, Elise Balse, Fabio Badillini, Christian Funck-Brentano, Joe-Elie Salem

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Metabolic phenotypes of doxorubicin-induced cardiotoxicity among patients with breast cancer.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Giacomo GravinaInstitute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 41390 Gothenburg, Sweden.ORCID 0000-0002-1695-4285
Melissa Y Y MoeyDepartment of Cardiovascular Sciences, East Carolina University (ECU) Health Medical Center, East Carolina University, Greenville, NC 27834, USA.
Edi PriftiIRD, Unité de Modélisation Mathématique et Informatique des Systèmes Complexes, Sorbonne Université, UMMISCO, F-93143 Bondy, France.
Farid IchouICAN Omics, Foundation for Innovation in Cardiometabolism and Nutrition (ICAN), Hôpital Pitié-Salpêtrière, F-75013 Paris, France.ORCID 0000-0001-6293-5133
Olivier BourronSorbonne Université Médecine, Assistance Publique Hôpitaux de Paris (APHP), Service de Diabétologie, Hôpital Pitié-Salpêtrière, INSERM UMRS_1138, Centre de Recherche des Cordeliers, Institute of Cardiometabolisme and Nutrition (ICAN), F-75013 Paris, France.
Elise BalseInstitute of Cardiometabolism and Nutrition (ICAN), INSERM, Sorbonne Université, UMR_S1166, F-75013 Paris, France.
Fabio BadilliniAMPS LLC, New York, NY 10041, USA.
Christian Funck-BrentanoDepartment of Pharmacology and Clinical Investigation Centre (CIC-1901), Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, INSERM, F-75013 Paris, France.ORCID 0000-0003-0406-5189
Joe-Elie SalemDepartment of Pharmacology and Clinical Investigation Centre (CIC-1901), Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, INSERM, F-75013 Paris, France.ORCID 0000-0002-0331-3307
Inserm · FREast Carolina University · USSorbonne Université · FR

Funding

the French Ministry of Health grant PHRC Code project: P111105; N◦ID RCB: 2013-A00896-39
6 · The paper itself

Abstract

Changes in the cardio-metabolomics profile and hormonal status have been associated with long QT syndrome, sudden cardiac death and increased mortality. The mechanisms underlying QTc duration are not fully understood. Therefore, an identification of novel markers that complement the diagnosis in these patients is needed. In the present study, we performed untargeted metabolomics on the sera of diabetic patients at a high risk of cardiovascular disease, followed up for 2.55 [2.34-2.88] years (

Indexed as

diabetesmetabolomicsN-Acetyl asparagineQTc

Identifiers

PMID36009502
PMCPMC9405979
OpenAlexW4291366452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.