ReviewBiomedicines2022
The Relationship between Stress, Inflammation, and Depression.
Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Epigenetic mechanisms affected by stress during adolescence and the increased risk for depression later in life: a systematic review.Molecular psychiatry · 2026Pooled it
- The impact of home-based telerehabilitation versus center-based cardiac rehabilitation on anxiety, depression, and quality of life after coronary artery bypass grafting: a randomized controlled trial.BMC cardiovascular disorders · 2026Trial
- Association between lifestyle inflammation score and quality of life according to depressive symptom status: a cross-sectional study in the Republic of Korea.Osong public health and research perspectives · 2026Article
- Revisiting 'environmental effects': Directions for multidisciplinary investigations of air quality and psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- The association between spatiotemporal coupling of default mode network and behaviors is specifically modulated by peripheral inflammation in major depressive disorder.BMC psychiatry · 2026Article
- Ketamine reduces microglial activation and brain monocyte infiltration and promotes peripheral regulatory immune cells, relieving lipopolysaccharide (LPS)-induced depressive-like behavior in mice.Molecular psychiatry · 2026Article
- Association between Sarcopenia-related traits and depression: an observational and Mendelian randomization analysis.European archives of psychiatry and clinical neuroscience · 2026Observational
- Mechanisms of exercise against anxiety disorder: A review of the research progress.Sports medicine and health science · 2026Review
- Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions.Nature reviews. Cardiology · 2026Review
- Promoting physical function in older adults via physical exercise from a health empowerment perspective: a chain mediation model of social participation and depression.BMC public health · 2026Article
- Molecular mechanism of Alzheimer's disease using integrated multi-omics.Frontiers in aging neuroscience · 2026Review
- Heterogeneous impacts of work-family conflict on workforce mental health: evidence from the differential effects of work-to-family and family-to-work conflict.Frontiers in public health · 2026Article
- Health Consequences of COVID-19 Pandemic in Older Adults with Musculoskeletal Conditions: A Cross-Sectional Path Analysis Model.Geriatrics (Basel, Switzerland) · 2025Article
- Dietary acid load and its association with psychological disorders, sleep quality, and mood among Iranian older adults: a cross-sectional study.BMC public health · 2025Article
- Apigenin exhibits memory enhancing activity through the restoration of oxido-endocrine balance and upregulation of BDNF/ERK/CREB signalling pathways in stressed mice.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Occupational Stressors and Workplace Challenges Faced by Seafarers in Lithuania: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Unveiling the neuroprotective potential of Jatropha humboldtiana leaves and its metabolic profiling by UPLC-MS/MS.Inflammopharmacology · 2025Article
- Interplay between Stressful Life Events and Interleukin-1β on 12-week Antidepressant Response in Depressive Patients.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Effect of depressive symptoms on treatment response in patients with axSpA: data from the RABBIT-SpA register.RMD open · 2025Observational
- The Magnitude of Anesthesiology Residents Burnout at Shahid Beheshti University of Medical Sciences: A Cross-Sectional Study.Anesthesiology and pain medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
A narrative review about the relationship between stress, inflammation, and depression is made as follows: Chronic stress leads to various stress-related diseases such as depression. Although most human diseases are related to stress exposure, the common pathways between stress and pathophysiological processes of different disorders are still debatable. Chronic inflammation is a crucial component of chronic diseases, including depression. Both experimental and clinical studies have demonstrated that an increase in the levels of pro-inflammatory cytokines and stress hormones, such as glucocorticoids, substantially contributes to the behavioral alterations associated with depression. Evidence suggests that inflammation plays a key role in the pathology of stress-related diseases; however, this link has not yet been completely explored. In this study, we aimed to determine the role of inflammation in stress-induced diseases and whether a common pathway for depression exists. Recent studies support pharmacological and non-pharmacological treatment approaches significantly associated with ameliorating depression-related inflammation. In addition, major depression can be associated with an activated immune system, whereas antidepressants can exert immunomodulatory effects. Moreover, non-pharmacological treatments for major depression (i.e., exercise) may be mediated by anti-inflammatory actions. This narrative review highlights the mechanisms underlying inflammation and provides new insights into the prevention and treatment of stress-related diseases, particularly depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.