ReviewBiomedicines2022
Increased Levels of HbA1c in Individuals with Type 2 Diabetes and Depression: A Meta-Analysis of 34 Studies with 68,398 Participants.
Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 5 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Behavioral Activation for Depression and Glycemic Control in Type 2 Diabetes: A Systematic Review and Meta-Analysis.Brain and behavior · 2026Pooled it
- Health risk behaviours, mental health and HbA1c: an overview of reviews of observational studies.BMJ open · 2025Pooled it
- Association of depression with glycaemic control in people living with diabetes in low- and middle-income countries: a systematic review and meta-analysis.BMJ global health · 2025Pooled it
- Effectiveness of continuous glucose monitoring in patient management of Type 2 Diabetes Mellitus: an umbrella review of systematic reviews from 2011 to 2024.Archives of public health = Archives belges de sante publique · 2024Pooled it
- Association between the triglyceride glucose index and depression: a meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Associations Between Sleep Quality and Continuous Glucose Monitoring-Derived Metrics in Individuals With Type 2 Diabetes.Journal of sleep research · 2026Article
- The relationship between fasting blood glucose, glycated hemoglobin, fructosamine, and depression in patients with type 2 diabetes mellitus in South Korea: a secondary analysis of the Korea National Health and Nutrition Examination Survey VIII-2 (2020) data.Journal of Korean biological nursing science · 2026Article
- Development and validation of a risk prediction model for demoralization syndrome in patients with type 2 diabetes.Frontiers in public health · 2026Observational
- Exploring the interplay of glucose metabolism, insulin resistance, and neurodegenerative pathologies: insights from streptozotocin and hypoglycaemic in vitro models.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- The Relationship Between Gestational Diabetes, Emotional Eating, and Clinical Indicators.Medicina (Kaunas, Lithuania) · 2025Article
- Trends in Depression Among Hospitalized Patients with Type 2 Diabetes in Spain (2017-2023): A Population-Based Analysis with a Focus on Sex Differences and In-Hospital Outcomes.Journal of clinical medicine · 2025Article
- PHQ-9, CES-D, health insurance data-who is identified with depression? A Population-based study in persons with diabetes.Diabetology & metabolic syndrome · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Glycosylated hemoglobin is used to diagnose type 2 diabetes mellitus and assess metabolic control. Depression itself has been associated with high levels of HbA1c in individuals with T2DM. The association between diabetes and depression suggests the usefulness of determining HbA1c as a biological marker of depressive symptoms. The aim of this study was to determine HbA1c levels in individuals with T2DM with vs. without depression. Additionally, we analyzed the influence of pharmacological treatments, time of evolution, and complications of disease. We performed a literature search in different databases published up to January 2020. A total of 34 articles were included. Our results showed that individuals with T2DM with depression showed increased levels of HbA1c in comparison to individuals with T2DM without depression (d = 0.18, 95% CI: 0.12−0.29, p(Z) < 0.001; I2 = 85.00). We also found that HbA1c levels remained elevated in individuals with T2DM with depression who were taking hypoglycemic drugs (d = 0.20 95% CI: 0.11−0.30, p(Z) < 0.001; I2 = 86.80), in individuals with less than 10 years of evolution (d = 0.17 95% CI: 0.09−0.26, p(Z) = 0.001; I2 = 66.03) and in individuals with complications of the disease (d = 0.17, 95% CI: 0.07−0.26, p(Z) < 0.001; I2 = 58.41). Our results show that HbA1c levels in individuals with T2DM with depression are significantly increased compared to controls with T2DM without depression. Additionally, these levels remained elevated in individuals who were taking hypoglycemic drugs, those with less than 10 years of disease evolution, and those with complications related to diabetes. It is necessary to examine the existence of a diabetes−HbA1c−depression connection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.