Evidence map›Paper›PMID 36009415›Full record

ArticleBiomedicines2022

IL-15/IL-15Rα in SJS/TEN: Relevant Expression of

Teresa Bellón, Olga González-Valle, Elena Sendagorta, Victoria Lerma, Javier Martínez Del Río, Celia Martínez, Guillermo Servera, Carlos González-Herrada, Lucía Cachafeiro, José A Lorente and 4 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Updates in the pathogenesis of SJS/TEN.Allergology international : official journal of the Japanese Society of Allergology · 2025
    Review
  3. Review
  4. Observational
  5. Review
  6. Review
  7. Severe cutaneous adverse reactions.Nature reviews. Disease primers · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Teresa BellónDrug Hypersensitivity Laboratory, Institute for Health Research Hospital Universitario La Paz (IdiPaz), 28046 Madrid, Spain.ORCID 0000-0002-0138-6879
Olga González-ValleDermatology Department, Hospital Universitario de Getafe, 28905 Getafe, Spain.ORCID 0000-0003-2571-4117
Elena SendagortaDermatology Department, Hospital Universitario La Paz-Carlos III-Cantoblanco, IdiPAZ, School of Medicine, Autonomous University of Madrid, 28049 Madrid, Spain.
Victoria LermaClinical Pharmacology Unit, Hospital Universitario Príncipe de Asturias, 28805 Alcalá de Henares, Spain.
Javier Martínez Del RíoDrug Hypersensitivity Laboratory, Institute for Health Research Hospital Universitario La Paz (IdiPaz), 28046 Madrid, Spain.
Celia MartínezDrug Hypersensitivity Laboratory, Institute for Health Research Hospital Universitario La Paz (IdiPaz), 28046 Madrid, Spain.
Guillermo ServeraDermatology Department, Hospital Universitario La Paz-Carlos III-Cantoblanco, IdiPAZ, School of Medicine, Autonomous University of Madrid, 28049 Madrid, Spain.ORCID 0000-0002-8439-0872
Carlos González-HerradaDermatology Department, Hospital Universitario de Getafe, 28905 Getafe, Spain.
Lucía CachafeiroDepartment of Intensive Care Medicine, Hospital Universitario La Paz, 28046 Madrid, Spain.ORCID 0000-0002-9750-1375
José A LorenteDepartment of Intensive Care Medicine, Hospital Universitario de Getafe, 28905 Getafe, Spain.ORCID 0000-0001-7679-9187
Rosario CabañasAllergy Department, Hospital Universitario La Paz-Carlos III-Cantoblanco, 28046 Madrid, Spain.
Pedro HerranzDermatology Department, Hospital Universitario La Paz-Carlos III-Cantoblanco, IdiPAZ, School of Medicine, Autonomous University of Madrid, 28049 Madrid, Spain.
Francisco de AbajoClinical Pharmacology Unit, Hospital Universitario Príncipe de Asturias, 28805 Alcalá de Henares, Spain.ORCID 0000-0001-9119-8646
PIELenRed Study
Hospital Universitario La Paz · ESHospital Universitario de Getafe · ESUniversidad de Alcalá · ESInstituto de Salud Carlos III · ES

Funding

Agencia Española de Medicamentos y Productos Sanitarios 2018/22706/011Instituto de Salud Carlos III PI13//01768 and PI18/00718
6 · The paper itself

Abstract

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening hypersensitivity reaction to medications characterized by keratinocyte apoptosis and skin detachment. IL-15 serum levels have been associated with severity and prognosis of SJS/TEN. We have measured IL-15 concentrations in serum and blister fluid (BF) from patients with SJS/TEN by ELISA and used quantitative RT-PCR to analyze the expression of

Indexed as

Il-15IL-15RαStevens–Johnson syndrometoxic epidermal necrolysis

Identifiers

PMID36009415
PMCPMC9405300
OpenAlexW4289523005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.