Evidence map›Paper›PMID 36009395›Full record

ReviewBiomedicines2022

Endothelial Dysfunction, Erectile Deficit and Cardiovascular Disease: An Overview of the Pathogenetic Links.

Federico De Leonardis, Gaia Colalillo, Enrico Finazzi Agrò, Roberto Miano, Andrea Fuschi, Anastasios D Asimakopoulos

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. The relationship between vitamin D levels and erectile dysfunction: A mini-review.Clinical and experimental reproductive medicine · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. The impact of PDE5 inhibitors on cardiovascular outcomes.Global cardiology science & practice · 2025
    Review
  17. Article
  18. Article
  19. Effects of Anti-Diabetic Drugs on Erectile Dysfunction: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Federico De LeonardisUnit of Urology, Department of Surgical Sciences, University of Rome Tor Vergata, 00133 Roma, Italy.
Gaia ColalilloUnit of Urology, Department of Surgical Sciences, University of Rome Tor Vergata, 00133 Roma, Italy.
Enrico Finazzi AgròUnit of Urology, Department of Surgical Sciences, University of Rome Tor Vergata, 00133 Roma, Italy.
Roberto MianoUnit of Urology, Department of Surgical Sciences, University of Rome Tor Vergata, 00133 Roma, Italy.ORCID 0000-0003-2445-1204
Andrea FuschiUrology Unit, Department of Medico-Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, 04100 Latina, Italy.
Anastasios D AsimakopoulosUnit of Urology, Fondazione PTV Policlinico Tor Vergata, 00185 Rome, Italy.ORCID 0000-0002-7230-579X
University of Rome Tor Vergata · ITPoliclinico Tor Vergata · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erectile dysfunction (ED) is a condition with multifactorial pathogenesis, quite common among men, especially those above 60 years old. A vascular etiology is the most common cause. The interaction between chronic inflammation, androgens, and cardiovascular risk factors determines macroscopically invisible alterations such as endothelial dysfunction and subsequent atherosclerosis and flow-limiting stenosis that affects both penile and coronary arteries. Thus, ED and cardiovascular disease (CVD) should be considered two different manifestations of the same systemic disorder, with a shared aetiological factor being endothelial dysfunction. Moreover, the penile arteries have a smaller size compared with coronary arteries; thus, for the same level of arteriopathy, a more significant blood flow reduction will occur in erectile tissue compared with coronary circulation. As a result, ED often precedes CVD by 2-5 years, and its diagnosis offers a time window for cardiovascular risk mitigation. Growing evidence suggests, in fact, that patients presenting with ED should be investigated for CVD even if they have no symptoms. Early detection could facilitate prompt intervention and a reduction in long-term complications. In this review, we provide an overview of the pathogenetic mechanisms behind arteriogenic ED and CVD, focusing on the role of endothelial dysfunction as the common denominator of the two disorders. Developed algorithms that may help identify those patients complaining of ED who should undergo detailed cardiologic assessment and receive intensive treatment for risk factors are also analyzed.

Indexed as

cardiovascular diseasescoronary artery diseaseendothelial dysfunctionerectile dysfunction

Identifiers

PMID36009395
PMCPMC9405076
OpenAlexW4289201620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.