Evidence map›Paper›PMID 36009383›Full record

ArticleBiomedicines2022

Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality.

Andreas Ritsch, Monika Hunjadi, Tatjana Stojakovic, Jürgen E Scherberich, Günther Silbernagel, Hubert Scharnagl, Graciela E Delgado, Marcus E Kleber, Winfried März

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Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Andreas RitschDepartment of Internal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-0417-5161
Monika HunjadiDepartment of Internal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-4285-2925
Tatjana StojakovicClinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, 8036 Graz, Austria.
Jürgen E ScherberichDepartment of Nephrology and Clinical Immunology, Klinikum Muenchen-Harlaching, Teaching Hospital of the Ludwig-Maximilians University, 81545 Munich, Germany.
Günther SilbernagelDivision of Angiology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-2750-006X
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Winfried MärzClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria.
Medical University of Graz · ATHeidelberg University · DEInnsbruck Medical University · ATMünchen Klinik Harlaching · DE

Funding

Austrian Science Fund FWF P 27116European Union 305739FWF Austrian Science Fund P27116_B23
6 · The paper itself

Abstract

backgroundImpaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (CKD). This has been attributed to abnormal HDL function in CKD.

methodsIn this study, we analyzed the association of genetic markers for kidney function with cholesterol efflux capacity as one of the major HDL functions, as well as with cardiovascular mortality, in 2469 patients of the Ludwigshafen Risk and Cardiovascular Health Study who all underwent coronary angiography.

resultsA genetic score of 53 SNPs associated with GRF and the uromodulin SNP rs12917707 were inversely correlated with cholesterol efflux capacity. This was in line with the observed association between cholesterol efflux capacity and kidney function in these patients. Adjustment for eGFR and uromodulin as markers of kidney function did not affect the relationship between cholesterol efflux and cardiovascular mortality.

conclusionsOur data propose the view that cholesterol efflux and kidney function are exerting their effects on cardiovascular mortality via different and independent pathways. Decreased cholesterol efflux may therefore not mediate the effects of impaired kidney function on cardiovascular mortality.

Indexed as

cardiovascular riskcholesterol efflux capacityhigh-density lipoproteinkidney functionsingle nucleotide polymorphismuromodulin

Identifiers

PMID36009383
PMCPMC9404976
OpenAlexW4289110523

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