ReviewBiomedicines2022
PMMA Bone Cement: Antibiotic Elution and Mechanical Properties in the Context of Clinical Use.
Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Advances in the Application of Multimodal Nano-Antimicrobial Strategies in Prosthetic Joint Infections: A Systematic Review.International journal of nanomedicine · 2025Pooled it
- Short or Long Antibiotic Regimens in Orthopedics.The New England journal of medicine · 2026Article
- Combined application of antibiotic bone cement and bone transport technique in tibial osteomyelitis with bone defect: A case report.Medicine · 2026Article
- Antimicrobial-loaded PMMA bone cement: time for good practice recommendations.The Journal of antimicrobial chemotherapy · 2026Article
- "Antimicrobial Brachytherapy" Protocol for Chronic Periprosthetic Joint Infection in Total Knee Arthroplasty: A Preliminary Case Series with 2-Year Results.Journal of clinical medicine · 2026Article
- Research progress and future prospects of antibacterial drug-loaded bone cement in the treatment of orthopedic infections.Journal of orthopaedic surgery and research · 2026Review
- Managing Bone Infections Beyond Systemic Antibiotics: A Scoping Review.Pathogens (Basel, Switzerland) · 2026Review
- The role of gut microbiota in osteoporosis: underlying mechanisms, clinical associations, and emerging biomaterials.Frontiers in immunology · 2026Review
- Safety of locally applied antibiotics in orthopaedic trauma surgery: descriptive results from a prospective cohort study.Journal of bone and joint infection · 2026Article
- Synergistic integration of biomaterials in orthopedic implantation for infection preventing and tissue engineering.Regenerative biomaterials · 2026Review
- Dual-antibiotic bone cement (gentamicin + vancomycin) in preventing and treating infections during revision knee arthroplasty in high-risk patients.Journal of experimental orthopaedics · 2026Article
- Article
- Point-of-care bone cement based on natural peptide comonomer protects orthopaedic implants from bacterial challenge.Materials today. Bio · 2025Article
- Biomechanical analysis of additional vancomycin in articulating knee spacers: determining the threshold for structural failure.Archives of orthopaedic and trauma surgery · 2025Article
- Current Concepts of Local Antibiotic Delivery in Bone and Joint Infections-A Narrative Review of Techniques and Clinical Experiences.Microorganisms · 2025Review
- Formulation and characterization of a sortase a inhibitor-loaded PMMA bone cement.RSC advances · 2025Article
- A Comparative Study of Extended Gentamicin and Tobramycin Release and Antibacterial Efficacy from Palacos and Simplex Acrylic Cements.Microorganisms · 2025Article
- Antibiotic Elution from Cement Spacers and Its Influencing Factors.Antibiotics (Basel, Switzerland) · 2025Review
- Cranioplasty Approaches and Outcomes in Low-Middle Income Countries: A Systematic Review.The Journal of craniofacial surgery · 2025Article
- Total knee arthroplasty revision risks depending on the bone cement used-Data from 50,545 knee replacements of the Catalan Arthroplasty Registry.Journal of experimental orthopaedics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This literature review discusses the use of antibiotic loaded polymethylmethacrylate bone cements in arthroplasty. The clinically relevant differences that have to be considered when antibiotic loaded bone cements (ALBC) are used either for long-term implant fixation or as spacers for the treatment of periprosthetic joint infections are outlined. In this context, in vitro findings for antibiotic elution and material properties are summarized and transferred to clinical use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.