Evidence map›Paper›PMID 36009365›Full record

ArticleBiomedicines2022

Relationship between the Soluble F11 Receptor and Annexin A5 in African Americans Patients with Type-2 Diabetes Mellitus.

Ajibola Adedayo, Ayobami Eluwole, Fasika Tedla, Arye Kremer, Muhammad Khan, Nicole Mastrogiovanni, Carl Rosenberg, Paul Dreizen, John La Rosa, Louis Salciccioli and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Ajibola AdedayoDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Ayobami EluwoleDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Fasika TedlaDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Arye KremerDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Muhammad KhanDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Nicole MastrogiovanniDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.ORCID 0000-0001-7333-9572
Carl RosenbergDepartment of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Paul DreizenDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
John La RosaDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Louis SalciccioliDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Mohamed BoutjdirDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Mary Ann BanerjiDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Clinton BrownDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Jason LazarDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.ORCID 0000-0002-8548-7932
Moro SalifuDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
Ahmed BakillahDepartment of Medicine, Downstate Medical Center, State University of New York, 450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.ORCID 0000-0001-5434-1976
State University of New York · USSUNY Downstate Health Sciences University · US

Funding

The New York State Department of Health ECRIP, 2015-2016
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is characterized by endothelial dysfunction, increased thrombogenicity, and inflammation. The soluble human F11 receptor (sF11R) and annexin A5 (ANXA5) play crucial roles in inflammatory thrombosis and atherosclerosis. We examined the relationship between circulating sF11R and ANXA5 and their impact on endothelial function. The study included 125 patients with T2DM. Plasma levels of sF11R and ANXA5 were quantified by ELISA. Microvascular function was assessed using the vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound imaging. The mean age of patients in the study was 59.7 ± 7.8 years, 78% had hypertension, 76% had dyslipidemia, and 12% had CKD. sF11R correlated positively with ANXA5 levels (β = 0.250, p = 0.005), and correlated inversely with VRI and total nitic oxide (NO), (β = −0.201, p = 0.024; β = −0.357, p = 0.0001, respectively). Multivariate regression analysis revealed that sF11R was independently associated with ANXA5 in the total population and in patients with HbA1c > 6.5% (β = 0.366, p = 0.007; β = 0.425, p = 0.0001, respectively). sF11R and ANXA5 were not associated with vascular outcome, suggesting that they may not be reliable markers of vascular dysfunction in diabetes. The clinical significance of sF11R/ANXA5 association in diabetes warrants further investigation in a larger population.

Indexed as

annexinsartery stiffnessbiomarkerscardiovascular diseasediabetesendothelium functionF11Rvascular complicationsvascular reactivity index

Identifiers

PMID36009365
PMCPMC9405000
OpenAlexW4288435677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.