Evidence map›Paper›PMID 36009310›Full record

ArticleAntioxidants (Basel, Switzerland)2022

New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique.

Aleksandra A Ageeva, Alexander I Kruppa, Ilya M Magin, Simon V Babenko, Tatyana V Leshina, Nikolay E Polyakov

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Silver Nanoparticles andInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aleksandra A AgeevaVoevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.ORCID 0000-0002-8670-0352
Alexander I KruppaVoevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.
Ilya M MaginVoevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.
Simon V BabenkoVoevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.
Tatyana V LeshinaVoevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.
Nikolay E PolyakovVoevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.ORCID 0000-0002-3666-7750

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electron transfer plays a crucial role in ROS generation in living systems. Molecular oxygen acts as the terminal electron acceptor in the respiratory chains of aerobic organisms. Two main mechanisms of antioxidant defense by exogenous antioxidants are usually considered. The first is the inhibition of ROS generation, and the second is the trapping of free radicals. In the present study, we have elucidated both these mechanisms of antioxidant activity of glycyrrhizin (GL), the main active component of licorice root, using the chemically induced dynamic nuclear polarization (CIDNP) technique. First, it was shown that GL is capable of capturing a solvated electron, thereby preventing its capture by molecular oxygen. Second, we studied the effect of glycyrrhizin on the behavior of free radicals generated by UV irradiation of xenobiotic, NSAID-naproxen in solution. The structure of the glycyrrhizin paramagnetic intermediates formed after the capture of a solvated electron was established from a photo-CIDNP study of the model system-the dianion of 5-sulfosalicylic acid and DFT calculations.

Indexed as

5-sulfosalicylic acidantioxidant activityfree radicalsglycyrrhizinnaproxenphoto-CIDNPsolvated electron

Identifiers

PMID36009310
PMCPMC9405345

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.