Evidence map›Paper›PMID 36009141›Full record

ArticleBrain sciences2022

Voxel-Mirrored Homotopic Connectivity Is Altered in Meibomian Gland Dysfunction Patients That Are Morbidly Obese.

Yi-Dan Shi, Hui-Ye Shu, Li-Qi Liu, Shi-Qi Li, Xu-Lin Liao, Yi-Cong Pan, Ting Su, Li-Juan Zhang, Min Kang, Ping Ying and 1 more

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In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Yi-Dan ShiDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Hui-Ye ShuDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Li-Qi LiuDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Shi-Qi LiDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Xu-Lin LiaoDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong 999077, China.
Yi-Cong PanDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Ting SuDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-0210-5482
Li-Juan ZhangDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Min KangDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Ping YingDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Yi ShaoDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.ORCID 0000-0003-1571-2433
Nanchang University · CNChinese University of Hong Kong · HKMassachusetts Eye and Ear Infirmary · US

Funding

Central Government Guides Local Science and Technology Development Foundation 20211ZDG02003Key Research Foundation of Jiangxi Province 20181BBG70004, 20203BBG73059National Natural Science Foundation 82160195
6 · The paper itself

Abstract

purposeTo investigate the altered functional connectivity (FC) of the cerebral hemispheres in patients with morbid obesity (MO) with meibomian gland dysfunction (MGD) by voxel-mirrored homotopic connectivity (VMHC).

methodsPatients and matched healthy controls (HCs) were recruited, and all subjects underwent functional resonance magnetic imaging (fMRI), and VMHC results were processed statistically to assess the differences in FC in different brain regions between the two groups. We further used ROC curves to evaluate the diagnostic value of these differences. We also used Pearson's correlation analysis to explore the relationship between changes in VMHC values in specific brain regions, visual acuity, and Mini-Mental State Examination (MMSE) score.

conclusionsPatients with morbid obesity and MGD had abnormal FC in the cerebral hemispheres in several specific brain areas, which were mainly concentrated in pathways related to vision and perception and may correlate to some extent with the clinical presentations of the patients.

Indexed as

fMRIfunctional connectivitymeibomian gland dysfunctionmorbid obesityvoxel-mirrored homotopic connectivity

Identifiers

PMID36009141
PMCPMC9405716
OpenAlexW4291378107

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.