Evidence map›Paper›PMID 36009092›Full record

ArticleBrain sciences2022

Resting-State Functional Connectivity Analyses: Brain Functional Reorganization in a Rat Model of Postherpetic Neuralgia.

Shuting Han, Guanzuan Wu, Xiang Wei, Xiaowen Meng, Fengchao Zang, Lan Shen, Hui Dai, Lina Wang, Yonggang Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shuting HanDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Guanzuan WuDepartment of Radiology, Shaoxing People's Hospital, Shaoxing 312000, China.ORCID 0000-0003-2099-3655
Xiang WeiDepartment of Endocrinology, Dushu Lake Hospital, Soochow University, Suzhou 215006, China.
Xiaowen MengDepartment of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Fengchao ZangJiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 211189, China.
Lan ShenTraditional Chinese Medicine Department, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Hui DaiDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Lina WangDepartment of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Yonggang LiDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Soochow University · CNShaoxing People's Hospital · CNZhongda Hospital Southeast University · CN

Funding

Suzhou Gusu Medical Youth Talent GSWS2020009Suzhou Gusu Medical Youth Talent GSWS2020019the Clinical Key Diseases Diagnosis and Therapy Special Project of Health and Family Planning Commission of Suzhou LCZX201801the High-level Health Personnel 'six-one' Project of Jiangsu Province in China LGY2016035the National Natural Science Foundation of China 81971573the Translational Research Grant of NCRCH 2020WSB06
6 · The paper itself

Abstract

Postherpetic neuralgia (PHN) is a chronic neuropathic pain syndrome, similar to other chronic pains, the mechanisms of which are not fully understood. To further understand the neural mechanism of this chronic pain and its transition, we performed functional magnetic resonance imaging (fMRI) scans on PHN rat models. Twelve PHN rat models were established by intraperitoneal injection of resiniferatoxin, with an additional 12 rats serving as controls. Nociceptive behavioral tests were performed on these rats and fMRI scans were performed on days 7 and 14 after modeling. Functional connection (FC) analysis was used to investigate the brain FC alterations associated with chronic pain in PHN rats, with the anterior cingulate cortex (ACC) as a seed. Nociceptive behavioral tests showed that PHN rats presented symptoms similar to those of PHN patients. FC analysis showed that compared to the control group, the PHN group showed different FC patterns on days 7 and 14. As can be seen, the brain FC alterations in the rat model of PHN changed dynamically, shifting from brain regions processing sensory information to regions processing emotions and motives.

Indexed as

chronic painmagnetic resonance imagingneuralgiapostherpeticrats

Identifiers

PMID36009092
PMCPMC9405817
OpenAlexW4289704777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.