Evidence map›Paper›PMID 36008977›Full record

ArticleBiomolecules2022

Vitamin A Deficiency Alters the Phototransduction Machinery and Distinct Non-Vision-Specific Pathways in the

Mukesh Kumar, Canan Has, Khanh Lam-Kamath, Sophie Ayciriex, Deepshe Dewett, Mhamed Bashir, Clara Poupault, Kai Schuhmann, Oskar Knittelfelder, Bharath Kumar Raghuraman and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Mukesh KumarMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.ORCID 0000-0002-3578-3506
Canan HasMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.ORCID 0000-0003-2355-3727
Khanh Lam-KamathDepartment of Biology, University of Massachusetts Boston, Integrated Sciences Complex, 100 Morrissey Boulevard, Boston, MA 02125, USA.
Sophie AyciriexMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.ORCID 0000-0003-4813-5900
Deepshe DewettDepartment of Biology, University of Massachusetts Boston, Integrated Sciences Complex, 100 Morrissey Boulevard, Boston, MA 02125, USA.ORCID 0000-0002-1022-5268
Mhamed BashirDepartment of Biology, University of Massachusetts Boston, Integrated Sciences Complex, 100 Morrissey Boulevard, Boston, MA 02125, USA.
Clara PoupaultDepartment of Biology, University of Massachusetts Boston, Integrated Sciences Complex, 100 Morrissey Boulevard, Boston, MA 02125, USA.
Kai SchuhmannMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.
Oskar KnittelfelderMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.ORCID 0000-0002-1565-7238
Bharath Kumar RaghuramanMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.
Robert AhrendsDepartment of Analytical Chemistry, University of Vienna, 1090 Vienna, Austria.
Jens RisterDepartment of Biology, University of Massachusetts Boston, Integrated Sciences Complex, 100 Morrissey Boulevard, Boston, MA 02125, USA.ORCID 0000-0002-0023-7417
Andrej ShevchenkoMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.ORCID 0000-0002-5079-1109
Max Planck Institute of Molecular Cell Biology and Genetics · DEUniversity of Massachusetts Boston · USUniversity of Vienna · AT

Funding

Mechanisms of vitamin A deprivation and replacement therapyR01EY029659 · NEI · UNIVERSITY OF MASSACHUSETTS BOSTON · PI RISTER, JENS · 2019 to 2023
$1.9M
NEI NIH HHS R01 EY029659NEI NIH HHS R01EY029659
6 · The paper itself

Abstract

The requirement of vitamin A for the synthesis of the visual chromophore and the light-sensing pigments has been studied in vertebrate and invertebrate model organisms. To identify the molecular mechanisms that orchestrate the ocular response to vitamin A deprivation, we took advantage of the fact that

Indexed as

Drosophila ProteinsVitamin A DeficiencyAnimalsDrosophilaDrosophila melanogasterLight Signal TransductionProteomeVitamin ADrosophila ProteinsProteomeVitamin ADrosophilalipidomemitochondrionphototransductionproteomeretinaretinalvitamin A

Identifiers

PMID36008977
PMCPMC9405971
OpenAlexW4290466590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.