Evidence map›Paper›PMID 36008960›Full record

ArticleBiomolecules2022

Calcium Binds to Transthyretin with Low Affinity.

Cristina Cantarutti, Maria Chiara Mimmi, Guglielmo Verona, Walter Mandaliti, Graham W Taylor, P Patrizia Mangione, Sofia Giorgetti, Vittorio Bellotti, Alessandra Corazza

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. A molecular basis for tetramer destabilization and aggregation of transthyretin Ala97Ser.Protein science : a publication of the Protein Society · 2023
    Article
  6. Microcalcification andInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Cristina CantaruttiDepartment of Medicine, University of Udine, 33100 Udine, Italy.ORCID 0000-0003-3435-9807
Maria Chiara MimmiDepartment of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100 Pavia, Italy.
Guglielmo VeronaWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK.
Walter MandalitiDepartment of Medicine, University of Udine, 33100 Udine, Italy.
Graham W TaylorWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK.
P Patrizia MangioneDepartment of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100 Pavia, Italy.
Sofia GiorgettiIstituto Nazionale Biostrutture e Biosistemi, 00136 Rome, Italy.
Vittorio BellottiIstituto Nazionale Biostrutture e Biosistemi, 00136 Rome, Italy.
Alessandra CorazzaDepartment of Medicine, University of Udine, 33100 Udine, Italy.ORCID 0000-0003-2272-1928
University of Pavia · ITUniversity of Udine · ITUniversity College London · GBIstituto Nazionale Biostrutture e Biosistemi · IT

Funding

Medical Research Council MR/R016984/1
6 · The paper itself

Abstract

The plasma protein transthyretin (TTR), a transporter for thyroid hormones and retinol in plasma and cerebrospinal fluid, is responsible for the second most common type of systemic (ATTR) amyloidosis either in its wild type form or as a result of destabilizing genetic mutations that increase its aggregation propensity. The association between free calcium ions (Ca

Indexed as

AmyloidosisPrealbuminCalciumHumansProteolysisCalciumPrealbuminamyloidosiscalcium dysregulationmechano-enzymatic mechanismmicrocalcificationTTR

Identifiers

PMID36008960
PMCPMC9406000
OpenAlexW4289521722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.