Evidence map›Paper›PMID 36008951›Full record

ArticleBiomolecules2022

Electrospun Core-Sheath Nanofibers with Variable Shell Thickness for Modifying Curcumin Release to Achieve a Better Antibacterial Performance.

Yubo Liu, Xiaohong Chen, Yuhang Gao, Yuyang Liu, Dengguang Yu, Ping Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yubo LiuSchool of Materials and Chemistry, University of Shanghai for Science & Technology, Shanghai 200093, China.
Xiaohong ChenSchool of Materials and Chemistry, University of Shanghai for Science & Technology, Shanghai 200093, China.
Yuhang GaoSchool of Materials and Chemistry, University of Shanghai for Science & Technology, Shanghai 200093, China.
Yuyang LiuSchool of Materials and Chemistry, University of Shanghai for Science & Technology, Shanghai 200093, China.
Dengguang YuSchool of Materials and Chemistry, University of Shanghai for Science & Technology, Shanghai 200093, China.ORCID 0000-0001-7825-4498
Ping LiuSchool of Materials and Chemistry, University of Shanghai for Science & Technology, Shanghai 200093, China.ORCID 0000-0002-9218-3531
University of Shanghai for Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inefficient use of water-insoluble drugs is a major challenge in drug delivery systems. Core-sheath fibers with various shell thicknesses based on cellulose acetate (CA) were prepared by the modified triaxial electrospinning for the controlled and sustained release of the water-insoluble Chinese herbal active ingredient curcumin. The superficial morphology and internal structure of core-sheath fibers were optimized by increasing the flow rate of the middle working fluid. Although the prepared fibers were hydrophobic initially, the core-sheath structure endowed fibers with better water retention property than monolithic fibers. Core-sheath fibers had flatter sustained-release profiles than monolithic fibers, especially for thick shell layers, which had almost zero-order release for almost 60 h. The shell thickness and sustained release of drugs brought about a good antibacterial effect to materials. The control of flow rate during fiber preparation is directly related to the shell thickness of core-sheath fibers, and the shell thickness directly affects the controlled release of drugs. The fiber preparation strategy for the precise control of core-sheath structure in this work has remarkable potential for modifying water-insoluble drug release and improving its antibacterial performance.

Indexed as

CurcuminNanofibersAnti-Bacterial AgentsDelayed-Action PreparationsWaterAnti-Bacterial AgentsCurcuminDelayed-Action PreparationsWatercore–sheath fiberselectrospinningsustained releasevariable sheath thicknesswater-insoluble drug

Identifiers

PMID36008951
PMCPMC9406017
OpenAlexW4289110740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.