ArticleCommunications biology2022
Developmental depression-to-facilitation shift controls excitation-inhibition balance.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Therapeutic Values of General Anesthetics: From Developmental Neurotoxicity to Neurotherapeutic Agents.Current neuropharmacology · 2026Review
- Acupressure Potentially Promoting the Learning and Memory Capabilities of Hypoxic Ischemic Cerebral Palsy Rats.Neural plasticity · 2026Article
- Network Activity Shapes Inhibitory Synaptic Development in the Mouse Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Recent Advances in Optoelectronic Synaptic Devices for Neuromorphic Computing.Biomimetics (Basel, Switzerland) · 2025Review
- Spatial evolution of the proton-coupled Mott transition in correlated oxides for neuromorphic computing.Science advances · 2024Article
- Article
- Self-organization of a doubly asynchronous irregular network state for spikes and bursts.PLoS computational biology · 2021Article
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Authors and funding
3 authors.
Funding
Abstract
Changes in the short-term dynamics of excitatory synapses over development have been observed throughout cortex, but their purpose and consequences remain unclear. Here, we propose that developmental changes in synaptic dynamics buffer the effect of slow inhibitory long-term plasticity, allowing for continuously stable neural activity. Using computational modeling we demonstrate that early in development excitatory short-term depression quickly stabilises neural activity, even in the face of strong, unbalanced excitation. We introduce a model of the commonly observed developmental shift from depression to facilitation and show that neural activity remains stable throughout development, while inhibitory synaptic plasticity slowly balances excitation, consistent with experimental observations. Our model predicts changes in the input responses from phasic to phasic-and-tonic and more precise spike timings. We also observe a gradual emergence of short-lasting memory traces governed by short-term plasticity development. We conclude that the developmental depression-to-facilitation shift may control excitation-inhibition balance throughout development with important functional consequences.
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Registered trials
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