Evidence map›Paper›PMID 36008672›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Characterization of the Effects of Candida Gastrointestinal Colonization on Clostridioides difficile Infection in a Murine Model.

Jesús A Romo, Carol A Kumamoto

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Clinical microbiology reviews · 2024
    Review
  3. Fungal and bacterial gut microbiota differ betweenMicrobiome research reports · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jesús A RomoDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
Carol A KumamotoDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA. carol.kumamoto@tufts.edu.

Funding

Tufts IRACDAK12GM133314 · NIGMS · TUFTS UNIVERSITY BOSTON · PI CLAIRE L MOORE, Jamie Lynn Maguire · 2019 to 2026
$8.4M
Interaction of enteropathogenic Yersinia and Vibrio cholera with engineered human intestinal tissueU19AI131126 · NIAID · TUFTS UNIVERSITY BOSTON · PI ISBERG, RALPH R. · 2017 to 2021
$8.1M
C ALBICANS IN THE GI TRACT ENVIRONMENTR01AI118898 · NIAID · TUFTS UNIVERSITY BOSTON · PI KUMAMOTO, CAROL A. · 2016 to 2020
$2.5M
NIAID NIH HHS R01 AI118898NIAID NIH HHS U19 AI131126NIGMS NIH HHS K12 GM133314
6 · The paper itself

Abstract

The role of fungal colonizers of the gastrointestinal tract during disease states is not well understood. Antibiotic treatment renders patients highly susceptible to infection by the bacterial pathogen C. difficile while also leading to blooms in fungal commensals, setting the stage for trans-kingdom interactions. Here, we describe a murine model of Candida gastrointestinal colonization coupled to a C. difficile infection (CDI) model, the measurement of CFU of both organisms, and collection of cecum and colon contents for the purpose of quantifying C. difficile toxin production. Additionally, we describe how to induce and purify C. difficile spores.

Indexed as

Clostridioides difficileClostridium InfectionsAnimalsCandidaDisease Models, AnimalGastrointestinal TractHumansMiceCandida albicansCandida glabrataClostridioides difficileGastrointestinal colonizationMurine model

Identifiers

PMID36008672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.