ArticleCommunications biology2022
Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
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Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Early cell-autonomous and niche-mediated epithelial response to influenza infection in primary alveolar organoids.JCI insight · 2026Article
- Optimized culture of primary human alveolar type II cell-derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling.Respiratory research · 2026Article
- Research Advances and Disease Modeling in Respiratory Organoids.Biomedicines · 2026Review
- Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model.The Journal of clinical investigation · 2026Article
- High-throughput isolation of normal and pulmonary fibrosis human alveolar epithelial cells.Scientific reports · 2025Article
- Microfluidic lung cancer models: Bridging clinical treatment strategies and tumor microenvironment recapitulation.APL bioengineering · 2025Review
- Distal lung organoids derived from adult stem cells as novel tools in deciphering mechanisms of lung regeneration, infection, and cancer.Stem cells translational medicine · 2025Review
- Comprehensive characterization of human alveolar epithelial cells cultured for 28 days at the air-liquid interface.Scientific reports · 2025Article
- Enhanced application potential of alveolar organoids through epithelial and niche cell interactions.Scientific reports · 2025Article
- Establishment of nasal and olfactory epithelium organoids for unveiling mechanism of tissue regeneration and pathogenesis of nasal diseases.Cellular and molecular life sciences : CMLS · 2025Review
- Selection of the Most Suitable Culture Medium for Patient-Derived Lung Cancer Organoids.Cells, tissues, organs · 2025Article
- Lung stem cells and respiratory epithelial chimerism in transplantation.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Generation of Human 3D Airway Assembloids for Advanced Modeling.International journal of biological sciences · 2025Article
- Advanced 3D imaging and organoid bioprinting for biomedical research and therapeutic applications.Advanced drug delivery reviews · 2024Review
- Glycogen Synthase Kinase-3 Inhibition by CHIR99021 Promotes Alveolar Epithelial Cell Proliferation and Lung Regeneration in the Lipopolysaccharide-Induced Acute Lung Injury Mouse Model.International journal of molecular sciences · 2024Article
- Flourishing tumor organoids: History, emerging technology, and application.Bioengineering & translational medicine · 2023Review
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Authors and funding
28 authors at 9 institutions in 1 country.
Karen Hoffmann *Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Benedikt Obermayer *Core Unit Bioinformatics, Berlin Institute of Health (BIH), Charite-Universitätsmedizin, Berlin, Germany.ORCID 0000-0002-9116-630X
Katja HönzkeDepartment of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Diana FatykhovaDepartment of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Zeynep DemirDepartment of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0001-5329-5517
Anna LöwaDepartment of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Luiz Gustavo Teixeira AlvesBerlin Institute for Medical Systems Biology (BIMSB), Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID 0000-0002-5822-4168
Emanuel WylerBerlin Institute for Medical Systems Biology (BIMSB), Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID 0000-0002-9884-1806
Elena Lopez-RodriguezInstitute of Functional Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Maren MiethDepartment of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Morris BaumgardtDepartment of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Judith HoppeInstitute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.
Theresa C FirschingInstitute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.ORCID 0000-0003-1378-4951
Mario TönniesHELIOS Clinic Emil von Behring, Department of Pneumology and Department of Thoracic Surgery, Chest Hospital Heckeshorn, Berlin, Germany.
Torsten T BauerHELIOS Clinic Emil von Behring, Department of Pneumology and Department of Thoracic Surgery, Chest Hospital Heckeshorn, Berlin, Germany.
Stephan EggelingDepartment of Thoracic Surgery, Vivantes Clinics Neukölln, Berlin, Germany.
Hong-Linh TranDepartment of Thoracic Surgery, Vivantes Clinics Neukölln, Berlin, Germany.
Paul SchneiderDepartment for General and Thoracic Surgery, DRK Clinics, Berlin, Germany.
Jens NeudeckerDepartment of General, Visceral, Vascular and Thoracic Surgery, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Jens C RückertDepartment of General, Visceral, Vascular and Thoracic Surgery, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Achim D GruberInstitute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.ORCID 0000-0002-4502-0393
Matthias OchsInstitute of Functional Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-0936-6979
Markus LandthalerBerlin Institute for Medical Systems Biology (BIMSB), Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID 0000-0002-1075-8734
Dieter BeuleCore Unit Bioinformatics, Berlin Institute of Health (BIH), Charite-Universitätsmedizin, Berlin, Germany.ORCID 0000-0002-3284-0632
Norbert SuttorpDepartment of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Stefan HippenstielDepartment of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Andreas C HockeDepartment of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Mirjana KesslerDepartment of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Mirjana.Kessler@med.uni-muenchen.de.ORCID 0000-0002-9879-1052
Humboldt-Universität zu Berlin · DEFreie Universität Berlin · DEMax Delbrück Center · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEHelios Klinikum Emil von Behring · DEVivantes Klinikum · DECharité - Universitätsmedizin Berlin · DEGerman Center for Lung Research · DELMU Klinikum · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanisms of epithelial renewal in the alveolar compartment remain incompletely understood. To this end, we aimed to characterize alveolar progenitors. Single-cell RNA-sequencing (scRNA-seq) analysis of the HTII-280
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LungOrganoidsCell DifferentiationGlycogen Synthase Kinase 3 betaHumansWnt Signaling PathwayGlycogen Synthase Kinase 3 beta
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