Evidence map›Paper›PMID 36008567›Full record

ReviewApplied microbiology and biotechnology2022

CRISPR-Cas system: from diagnostic tool to potential antiviral treatment.

Aishwarya Rajan, Stuti Shrivastava, Janhawi, Akhilesh Kumar, Alok Kumar Singh, Pankaj Kumar Arora

Open access · bronzeAbstract readReview
In one paragraph

Review in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
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  7. The role of viral diagnostic tests in respiratory tract infections: moving forward.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Aishwarya RajanDr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India.
Stuti ShrivastavaElectronics and Communication, Jaypee Institute of Information Technology, Noida, India.
JanhawiDepartment of Zoology, Kalindi College, University of Delhi, Delhi, India.
Akhilesh KumarDepartment of Botany, Banaras Hindu University, Varanasi, India. akhilesh.kumar@bhu.ac.in.
Alok Kumar SinghDepartment of Biochemistry, Shaheed Rajguru College of Applied Sciences for Women, University of Delhi, Delhi, India. alokjnu18@gmail.com.
Pankaj Kumar AroraDepartment of Environmental Microbiology, Babasaheb Bhimrao Ambedkar University, Lucknow, India. arora484@gmail.com.ORCID http://orcid.org/0000-0002-4106-8859
University of Delhi · INBabasaheb Bhimrao Ambedkar University · INBanaras Hindu University · INJaypee Institute of Information Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This mini review focuses on the diagnosis and treatment of virus diseases using Crisper-Cas technology. The present paper describes various strategies involved in diagnosing diseases using Crispr-Cas-based assays. Additionally, CRISPR-Cas systems offer great potential as new therapeutic tools for treating viral infections including HIV, Influenza, and SARS-CoV-2. There are several major challenges to be overcome before this technology can be applied routinely in clinical settings, such as finding a suitable delivery tool, toxicity, and immunogenicity, as well as off-target effects. This review also discusses ways to deal with the challenges associated with Crisper-Cas technology. KEY POINTS: • Crisper technology is being applied to diagnose infectious and non-infectious diseases. • A new generation of CRISPR-Cas-based assays has been developed which detect pathogens within minutes, providing rapid diagnosis of diseases. • Crispr-Cas tools can be used to combat viral infections, specifically HIV, influenza, and SARS-CoV-2.

Indexed as

COVID-19COVID-19 Drug TreatmentHIV InfectionsInfluenza, HumanVirus DiseasesAntiviral AgentsCOVID-19 TestingCRISPR-Cas SystemsHumansSARS-CoV-2Antiviral AgentsCrispr-CasHIVInfluenzaSARS-CoV-2

Identifiers

PMID36008567
PMCPMC9411046
OpenAlexW4293093426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.