Evidence map›Paper›PMID 36008521›Full record

SynthesisJournal of perinatology : official journal of the California Perinatal Association2022

Dual medication therapy (acetaminophen and ibuprofen) for the management of patent ductus arteriosus in preterm infants: a systematic review and meta-analysis.

Sanket D Shah, Kartikeya Makker, Mingyu Zhang, Susan Harnett, Khyzer B Aziz, Mark L Hudak

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sanket D ShahDivision of Neonatology, Department of Pediatrics, University of Florida College of Medicine, Jacksonville, FL, USA. sdshah_5@yahoo.com.ORCID 0000-0002-1033-0156
Kartikeya MakkerDivision of Neonatology, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University, Baltimore, MD, USA.
Mingyu ZhangDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-3628-0983
Susan HarnettNemours Children's Health, Jacksonville, FL, USA.
Khyzer B AzizDivision of Neonatology, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University, Baltimore, MD, USA.
Mark L HudakDivision of Neonatology, Department of Pediatrics, University of Florida College of Medicine, Jacksonville, FL, USA.ORCID 0000-0001-9405-3522
Johns Hopkins University · USUniversity of Florida · USNemours Children's Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the efficacy of dual medication therapy (intervention) (DMT: acetaminophen and ibuprofen) vs. single medication therapy (control) (SMT: ibuprofen) for medical management of PDA (outcomes) in preterm infants (population). STUDY

designWe systematically searched multiple sources to identify randomized controlled trials (RCT) and non-randomized studies (NRS) that compared DMT to SMT for management of hemodynamically significant PDA.

resultsWe identified two RCTs and four NRS. There were no differences in the rates of successful PDA closure following the first treatment course between DMT and SMT (RR = 1.23 [95% CI 0.89-1.70] for NRS and RR = 1.18 [95% CI 0.66-2.10] for RCTs), nor were there significant differences in secondary outcomes and adverse events including PDA ligation, bronchopulmonary dysplasia, and necrotizing enterocolitis etc. Markers of hepatic/renal function did not change significantly during treatment.

conclusionWe found no evidence for superiority of DMT over SMT in PDA management.

Indexed as

Ductus Arteriosus, PatentAcetaminophenHumansIbuprofenIndomethacinInfant, Low Birth WeightInfant, NewbornInfant, PrematureAcetaminophenIbuprofenIndomethacin

Identifiers

PMID36008521
OpenAlexW4293101527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.