Evidence map›Paper›PMID 36008480›Full record

ReviewNature cell biology2022

Mammalian genome innovation through transposon domestication.

Andrew J Modzelewski, Johnny Gan Chong, Ting Wang, Lin He

Abstract readReview
In one paragraph

Review in Nature cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
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  8. Chromosome-Level Genome Assembly ofJournal of fungi (Basel, Switzerland) · 2026
    Article
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  12. Review
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  14. Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew J ModzelewskiDivision of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-0698-957X
Johnny Gan ChongDivision of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, CA, USA.
Ting WangDepartment of Genetics, Edison Family Center for Genome Science and System Biology, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6800-242X
Lin HeDivision of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, CA, USA. lhe@berkeley.edu.ORCID http://orcid.org/0000-0001-5928-1263

Funding

The WashU-UCSC-EBI Human Genome Reference Center."U41HG010972 · NHGRI · WASHINGTON UNIVERSITY · PI Ira M Hall, Heng Li · 2019 to 2026
$24.9M
GENCODE: comprehensive reference genome annotation for human and mouseU24HG007234 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI Fergal James Martin · 2021 to 2026
$16.1M
WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating CenterU24HG012070 · NHGRI · WASHINGTON UNIVERSITY · PI Ting Wang, Feng Yue · 2021 to 2026
$9.7M
THE WASHU TARGET ENVIRONMENTAL EPIGENOMICS DATA COORDINATION CENTERU24ES026699 · NIEHS · WASHINGTON UNIVERSITY · PI WANG, TING · 2016 to 2021
$5.2M
miR-200 miRNAs repress tumor metastasis in lung adenocarcinomaR01CA139067 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2009 to 2021
$3.3M
Retrotransposon derived promoters drive alternative host gene isoforms with important developmental functionsR01HD106809 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI Lin He · 2022 to 2026
$2.8M
DECODING THE IMPACT OF TRANSPOSABLE ELEMENTS ON GENE REGULATIONR01HG007175 · NHGRI · WASHINGTON UNIVERSITY · PI WANG, TING · 2014 to 2021
$2.7M
Choroid Plexus Multi-Sensory Cilia Regulate Production of Cerebrospinal FluidR01NS120287 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2021 to 2025
$2.5M
Connecting transposable elements and regulatory innovation using ENCODE dataU01HG009391 · NHGRI · WASHINGTON UNIVERSITY · PI COHEN, BARAK A, FESCHOTTE, CEDRIC · 2017 to 2021
$2.4M
The WashU 4DN Network Data Coordination and Integration CenterU01CA200060 · NCI · WASHINGTON UNIVERSITY · PI WANG, TING · 2015 to 2019
$1.9M
Characterize the role of miR-34/449 miRNAs in regulating motile ciliogenesisR01GM114414 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2015 to 2018
$1.2M
The Role of Retrotransposon Activity in Mammalian Pre-Implantation DevelopmentR00HD096108 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI MODZELEWSKI, ANDREW JOSEPH · 2022 to 2024
$744k
Howard Hughes Medical InstituteNCI NIH HHS R01 CA139067NCI NIH HHS U01 CA200060NHGRI NIH HHS R01 HG007175NHGRI NIH HHS U01 HG009391NHGRI NIH HHS U24 HG007234NHGRI NIH HHS U24 HG012070NHGRI NIH HHS U41 HG010972NICHD NIH HHS K99 HD096108NICHD NIH HHS R00 HD096108NICHD NIH HHS R01 HD106809NIEHS NIH HHS U24 ES026699NIGMS NIH HHS R01 GM114414NIH HHS R21 OD027053NINDS NIH HHS R01 NS120287
6 · The paper itself

Abstract

Since the discovery of transposons, their sheer abundance in host genomes has puzzled many. While historically viewed as largely harmless 'parasitic' DNAs during evolution, transposons are not a mere record of ancient genome invasion. Instead, nearly every element of transposon biology has been integrated into host biology. Here we review how host genome sequences introduced by transposon activities provide raw material for genome innovation and document the distinct evolutionary path of each species.

Indexed as

DNA Transposable ElementsDomesticationAnimalsEvolution, MolecularMammalsDNA Transposable Elements

Identifiers

PMID36008480
PMCPMC9729749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.