ArticleNature communications2022
Discrete subicular circuits control generalization of hippocampal seizures.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 55 citations in OpenAlex.
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- Acquired pharmacoresistance in temporal lobe epilepsy is driven by NaActa pharmaceutica Sinica. B · 2026Article
- Fibronectin1-Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Perirhinal cortex gains control of hippocampal seizures via broad downstream circuits in male mouse models.Nature communications · 2026Article
- Brain morphometry, stimulation charge, and seizure duration in electroconvulsive therapy.Molecular psychiatry · 2026Article
- Neural circuit mechanisms of epilepsy: Maintenance of homeostasis at the cellular, synaptic, and neurotransmitter levels.Neural regeneration research · 2026Article
- Subicular Astrocytes Govern Seizure-Impaired Fear Memory.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ventral subicular pyramidal neurons contribute to epileptogenesis via anterior thalamic circuit.Communications biology · 2025Article
- Deep brain stimulation of the anterior nucleus of the thalamus in animal models of mesial temporal lobe epilepsy: A literature review.Epilepsy research · 2025Review
- Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures.Nature chemical biology · 2025Article
- A dorsal subiculum-medial mammillary body pathway for spatial memory.Molecular psychiatry · 2025Article
- Intersection of epilepsy and cardiac health: Insights from electrocardiography and syndromic associations.Epilepsia · 2025Review
- An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus.Nature neuroscience · 2025Article
- Huperzine A attenuates epileptic seizures via enhancing dCA1-projecting septal cholinergic transmission.Acta pharmacologica Sinica · 2025Article
- Article
- Atypical hippocampal excitatory neurons express and govern object memory.Nature communications · 2025Article
- Low-Frequency Stimulation at the Ventromedial Hypothalamus Exhibits Broad-Spectrum Efficacy Across Models of Epilepsy.CNS neuroscience & therapeutics · 2025Article
- Cholecystokinin facilitates the formation of long-term heterosynaptic plasticity in the distal subiculum.Communications biology · 2025Article
- Circuit Reorganization of Subicular Cell-Type-Specific Interneurons in Temporal Lobe Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hyperpolarization-activated cyclic nucleotide-gated channels and epilepsy: genetics, circuits, and treatments.Frontiers in neurology · 2025Review
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-inhibition, it is therapeutically necessary to identify key brain regions and related circuits in epilepsy. The subiculum is an essential participant in epileptic seizures, but the circuit mechanism underlying its role remains largely elusive. Here we deconstruct the diversity of subicular circuits in a mouse model of epilepsy. We find that excitatory subicular pyramidal neurons heterogeneously control the generalization of hippocampal seizures by projecting to different downstream regions. Notably, anterior thalamus-projecting subicular neurons bidirectionally mediate seizures, while entorhinal cortex-projecting subicular neurons act oppositely in seizure modulation. These two subpopulations are structurally and functionally dissociable. An intrinsically enhanced hyperpolarization-activated current and robust bursting intensity in anterior thalamus-projecting neurons facilitate synaptic transmission, thus contributing to the generalization of hippocampal seizures. These results demonstrate that subicular circuits have diverse roles in epilepsy, suggesting the necessity to precisely target specific subicular circuits for effective treatment of epilepsy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.