ArticleNature communications2022
Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Article
- Presynaptic inhibition selectively suppresses leg proprioception in behavingbioRxiv : the preprint server for biology · 2024Article
- Mind In Vitro Platforms: Versatile, Scalable, Robust, and Open Solutions to Interfacing with Living Neurons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A leg model based on anatomical landmarks to study 3D joint kinematics of walking inFrontiers in bioengineering and biotechnology · 2024Article
- Mechanosensory Control of Locomotion in Animals and Robots: Moving Forward.Integrative and comparative biology · 2023Review
- Article
- Ascending neurons convey behavioral state to integrative sensory and action selection brain regions.Nature neuroscience · 2023Article
- Descending neuron population dynamics during odor-evoked and spontaneous limb-dependent behaviors.eLife · 2022Article
- NeuroMechFly, a neuromechanical model of adult Drosophila melanogaster.Nature methods · 2022Article
- Economic Order Quantity Model-Based Optimized Fuzzy Nonlinear Dynamic Mathematical Schemes.Computational intelligence and neuroscience · 2022Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dynamics and connectivity of neural circuits continuously change on timescales ranging from milliseconds to an animal's lifetime. Therefore, to understand biological networks, minimally invasive methods are required to repeatedly record them in behaving animals. Here we describe a suite of devices that enable long-term optical recordings of the adult Drosophila melanogaster ventral nerve cord (VNC). These consist of transparent, numbered windows to replace thoracic exoskeleton, compliant implants to displace internal organs, a precision arm to assist implantation, and a hinged stage to repeatedly tether flies. To validate and illustrate our toolkit we (i) show minimal impact on animal behavior and survival, (ii) follow the degradation of chordotonal organ mechanosensory nerve terminals over weeks after leg amputation, and (iii) uncover waves of neural activity caffeine ingestion. Thus, our long-term imaging toolkit opens up the investigation of premotor and motor circuit adaptations in response to injury, drug ingestion, aging, learning, and disease.
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