Evidence map›Paper›PMID 36008121›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

First-in-Humans Evaluation of Safety and Dosimetry of

Richard Laforest, Anchal Ghai, Tyler J Fraum, Reiko Oyama, Jennifer Frye, Helen Kaemmerer, Greg Gaehle, Tom Voller, Cedric Mpoy, Buck E Rogers and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. My Perspective on OBOC Combinatorial Technology.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  10. Article
  11. Review
  12. Dosimetry of [medRxiv : the preprint server for health sciences · 2024
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Molecular imaging of bone metastasis.Journal of bone oncology · 2023
    Review
  18. Biodistribution, Dosimetry, and Pharmacokinetics ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  19. Peptidomimetics in cancer targeting.Molecular medicine (Cambridge, Mass.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Richard LaforestAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Anchal GhaiEdward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Tyler J FraumAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Reiko OyamaEdward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Jennifer FryeEdward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Helen KaemmererEdward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Greg GaehleEdward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Tom VollerEdward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Cedric MpoyDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.
Buck E RogersAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Mark FialaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and.
Kooresh I ShoghiAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Samuel AchilefuAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Michael RettigAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Ravi VijAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
John F DiPersioAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Sally SchwarzEdward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Monica ShokeenAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; dehdashtif@wustl.edu mshokeen@wustl.edu.
Farrokh DehdashtiAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; dehdashtif@wustl.edu mshokeen@wustl.edu.
Mallinckrodt (United States) · USWashington University in St. Louis · USAlvin J. Siteman Cancer Center

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Project 2 - Radiation-Induced Treatment of Multiple Myeloma using NanoparticlesU54CA199092 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2019
$11.5M
Optimizing Hematopoietic Stem Cell Transplantation For The Treatment Of Hematological MalignanciesR35CA210084 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio · 2017 to 2026
$7.8M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPYR01CA260855 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2021 to 2025
$3.5M
Exploring CD38 molecular biology and imaging in multiple myeloma pathogenesisR01CA248493 · NCI · WASHINGTON UNIVERSITY · PI SHOKEEN, MONICA · 2020 to 2024
$3.1M
Development and Commercialization of a New Molecularly Targeted Imaging Agent for Multiple MyelomaR42CA257797 · NCI · SARYA, LLC · PI BEREZIN, MIKHAIL Y. · 2021 to 2024
$2.5M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPY OF TUMORSR01EB021048 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2020
$2.3M
BM NICHE DISRUPTION AND IMMUNOTHERAPY IN HEMATOLOGICAL MALIGNANCIESR50CA211466 · NCI · WASHINGTON UNIVERSITY · PI Michael Rettig · 2016 to 2026
$2.3M
RECEPTOR TARGETED MOLECULAR IMAGING OF MULTIPLE MYELOMAR01CA176221 · NCI · WASHINGTON UNIVERSITY · PI SHOKEEN, MONICA · 2013 to 2015
$946k
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA176221NCI NIH HHS R01 CA248493NCI NIH HHS R01 CA260855NCI NIH HHS R35 CA210084NCI NIH HHS R42 CA257797NCI NIH HHS R50 CA211466NCI NIH HHS U54 CA199092NIBIB NIH HHS R01 EB021048
6 · The paper itself

Abstract

There remains an unmet need for molecularly targeted imaging agents for multiple myeloma (MM). The integrin very late antigen 4 (VLA4), is differentially expressed in malignant MM cells and in pathogenic inflammatory microenvironmental cells. [

Indexed as

Multiple MyelomaPositron Emission Tomography Computed TomographyAnimalsFemaleHumansMaleMiceMice, Inbred ICRPositron-Emission TomographyRadiometryRadiopharmaceuticalsTissue DistributionRadiopharmaceuticalsdosimetryfirst-in-humansradiochemistryradiopharmaceuticalssafetytranslational imaging

Identifiers

PMID36008121
PMCPMC9902845
OpenAlexW4293080087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.