Evidence map›Paper›PMID 36007985›Full record

ArticleJournal of the American College of Cardiology2022

Polygenic Risk Score Predicts Sudden Death in Patients With Coronary Disease and Preserved Systolic Function.

Roopinder K Sandhu, Jacqueline S Dron, Yunxian Liu, M Vinayaga Moorthy, Neal A Chatterjee, Patrick T Ellinor, Daniel I Chasman, Nancy R Cook, Amit V Khera, Christine M Albert

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01114269 (PRE-DETERMINE), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01114269 active not recruitingnot on this map

PRE-DETERMINE: Biologic Markers and MRI SCD Cohort Study

TypeobservationalSponsorBrigham and Women's HospitalRan2007 to 2026Enrolled5,764ConditionsCoronary Artery Disease, Left Ventricular Dysfunction, Sudden Cardiac Death
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Sudden death in ischemic heart disease: looking for new predictors: polygenic risk.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Roopinder K SandhuDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada.
Jacqueline S DronCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Yunxian LiuDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
M Vinayaga MoorthyDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Neal A ChatterjeeDivision of Cardiology, University of Washington, Seattle, Washington, USA.
Patrick T EllinorDivision of Cardiology and Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Nancy R CookDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Amit V KheraCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Division of Cardiology and Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Christine M AlbertDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address: Christine.albert@cshs.org.
Brigham and Women's Hospital · USBroad Institute · USCedars-Sinai Smidt Heart Institute · USCedars-Sinai Medical Center · USMassachusetts General Hospital · USUniversity of Washington · US

Funding

PRE-DETERMINE: Biologic Markers and MRI SCD Cohort StudyR01HL091069 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALBERT, CHRISTINE M · 2008 to 2020
$12.9M
Enabling improved applicability and transferability of polygenic scores across populationsU01HG011719 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Alicia Martin · 2021 to 2026
$5.5M
Polygenic prediction of common, complex diseasesK08HG010155 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI KHERA, AMIT VIKRAM · 2018 to 2021
$1.1M
NHGRI NIH HHS K08 HG010155NHGRI NIH HHS U01 HG011719NHLBI NIH HHS R01 HL091069
6 · The paper itself

Abstract

backgroundA familial predisposition to sudden and/or arrhythmic death (SAD) in the setting of coronary artery disease (CAD) exists; however, the genetic basis is poorly understood.

objectivesThe purpose of this study was to determine whether a genome-wide polygenic score for coronary artery disease (GPS

methodsA previously validated GPS

resultsOver a median follow-up of 8.0 years, participants in the top GPS

conclusionsAmong CAD patients without severe systolic dysfunction, high GPS

Indexed as

Coronary Artery DiseaseDeath, Sudden, CardiacHumansRisk AssessmentRisk FactorsStroke VolumeVentricular Function, Leftcoronary artery diseasepolygenic risk scoresudden death

Identifiers

PMID36007985
PMCPMC10460525
OpenAlexW4292664161

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.