ArticleBMJ case reports2022
Sertoli-Leydig cell ovarian tumour: a rare cause of virilisation and androgenic alopecia.
Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Primary High-Grade Ovarian Sertoli-Leydig Cell Tumor With Bilateral Adnexal Involvement in a Patient Diagnosed With Peutz-Jeghers Syndrome.Case reports in oncological medicine · 2025Article
- Does surgery to preserve fertility in Sertoli-Leydig cell tumours increase the likelihood of spontaneous conception?BMJ case reports · 2024Article
- Study of the Thyroid Profile of Patients with Alopecia.Journal of clinical medicine · 2023Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sertoli-Leydig cell tumours (SLCTs) represent a rare cause of hyperandrogenic state. SLCTs are sex cord ovarian neoplasms, accounting for <0.2% of all ovarian tumours. Most of the sex cord-stromal tumours have a benign clinical course, with 10%-20% of them at risk of aggressive course. We report a case of a woman in her 30s who presented with androgenic alopecia, virilisation and secondary amenorrhoea. The evaluation revealed an extremely high testosterone level. Imaging for the localisation of source of excess testosterone with contrast-enhanced CT of the abdomen revealed a right ovarian mass. Hence, a diagnosis of testosterone-secreting ovarian tumour was considered. The patient underwent right salphingo-oophorectomy, and histopathology was reported as Sertoli cell tumour. Postoperatively, there was normalisation of serum testosterone levels with decrease in virilisation and resumption of spontaneous menstrual cycles. The patient conceived spontaneously after 2 months of surgery.
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