ArticleNature2022
Embryo model completes gastrulation to neurulation and organogenesis.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 1 pooled it
20.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 1 synthesis or guideline pooled it, 244 citations in OpenAlex.
- Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature.Stem cell research & therapy · 2023Pooled it
- Real-time sensing-integrated organoid-on-a-chip platforms: Technological progress and emerging biomedical applications.Bioactive materials · 2026Review
- Review
- The dual-enhanced graph learning framework DePass allows paired data integration in single-cell and spatial multiomics.Nature cell biology · 2026Article
- Article
- Lineage tracing in gastruloids to understand determinants of early fate decisions.Current opinion in genetics & development · 2026Review
- Epigenetic blind spots - the role of DNA methylation dynamics in stem cell-based models of embryogenesis.FEBS letters · 2026Article
- Embryo quality control via lineage-specific aneuploid cell elimination in embryos and stem cell-derived embryo models.Nature communications · 2026Article
- Decoding the origins of cellular self-organization for engineered biology.Nature biotechnology · 2026Review
- Para-uterine imaging protocol: Stabilizing living mouse embryos within the maternal abdomen for in vivo imaging and visually guided physiology.STAR protocols · 2026Article
- Article
- Human stem cell-based embryo models: innovation, ethics, and policy.Human reproduction (Oxford, England) · 2026Article
- Fuel to fire: developmental niche-empowered ApoEVs unlock adult hierarchical tissue regenerative potential via mitochondrial complex I-driven developmental metabolic profile.International journal of oral science · 2026Article
- The vertebrate yolk sac: evolutionary origins and current advances in in vitro models.Development (Cambridge, England) · 2026Review
- Stem cell-based embryo models as a tool for reproductive biology.Molecular human reproduction · 2026Review
- Morally relevant features warranting ethical oversight in human stem cell-based embryo models.Nature cell biology · 2026Review
- Stage-specific epigenetic priming amplifies gene activation during lineage commitment.Science advances · 2026Article
- Organoid Technology as a Promising Frontier in Organ Transplantation and Regenerative Medicine.International journal of stem cells · 2026Review
- Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model.bioRxiv : the preprint server for biology · 2026Article
- Organizers in a dish: Modeling human CNS morphogenesis.Developmental cell · 2026Review
83 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 4 countries.
Gianluca Amadei *Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Charlotte E Handford *Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5245-8027
Chengxiang QiuDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6346-8669
Joachim De JongheDepartment of Biochemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0584-8265
Hannah GreenfeldDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Martin TranDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Beth K MartinDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9661-014X
Dong-Yuan ChenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-2179-2847
Alejandro Aguilera-CastrejonDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-1339-7778
Jacob H HannaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0003-2042-9974
Michael B ElowitzDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-1221-0967
Florian HollfelderDepartment of Biochemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-1367-6312
Jay ShendureDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1516-1865
David M GloverDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Magdalena Zernicka-GoetzDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. magdaz@caltech.edu.ORCID http://orcid.org/0000-0002-7004-2471
California Institute of Technology · USUniversity of Cambridge · GBUniversity of Washington · USWeizmann Institute of Science · ILHoward Hughes Medical Institute · US
Funding
UW 4-Dimensional Genomic Organization of Mammalian Embryogenesis CenterUM1HG011586 · NHGRI · UNIVERSITY OF WASHINGTON · PI DISTECHE, CHRISTINE M., NOBLE, WILLIAM STAFFORD · 2020 to 2024
$10.3MMEMOIR: Recording, and in situ readout of cell lineage and transcriptional historyR01MH116508 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CAI, LONG, ELOWITZ, MICHAEL B · 2017 to 2021
$6.9MVersatile, exponentially scalable methods for single cell molecular profilingR01HG010632 · NHGRI · UNIVERSITY OF WASHINGTON · PI Jay Ashok Shendure, Bruce Colston Trapnell · 2019 to 2026
$5.9MPlacental models to support embryogenesis in vitroDP1HD104575 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ZERNICKA-GOETZ, MAGDALENA · 2020 to 2024
$5.8MBiological mechanisms that eliminate aneuploid cells from a mosaic conceptus in the mouse model systemR01HD101489 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ZERNICKA-GOETZ, MAGDALENA · 2021 to 2025
$2.6MMechanistic roles of the basement membrane mechanics in cellular morphodynamics and tissue patterning of the pre-gastrulating embryoF32HD105442 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHEN, DONG-YUAN · 2021 to 2023
$166kEuropean Research Council 669198Howard Hughes Medical InstituteNHGRI NIH HHS R01 HG010632NHGRI NIH HHS UM1 HG011586NICHD NIH HHS DP1 HD104575NICHD NIH HHS F32 HD105442NICHD NIH HHS R01 HD101489NIMH NIH HHS R01 MH116508Wellcome TrustWellcome Trust 207415/Z/17/ZWellcome Trust WT108438/C/15/Z
Abstract
Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in vitro
Indexed as
Embryo, MammalianGastrulationModels, BiologicalNeurulationOrganogenesisAnimalsCell LineageEmbryonic Stem CellsEndodermHeartMesencephalonMiceNeural TubePAX6 Transcription FactorProsencephalonSomitesPax6 protein, mousePAX6 Transcription Factor
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.