Evidence map›Paper›PMID 36007528›Full record

ArticleCurrent biology : CB2022

Nascent transcriptome reveals orchestration of zygotic genome activation in early embryogenesis.

Hui Chen, Matthew C Good

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Regulation of zygotic genome activation by the nucleocytoplasmic ratio.Frontiers in cell and developmental biology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Quantifying Nascent Transcription in Early Embryogenesis.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Principles of genome activation in the early embryo.Current opinion in genetics & development · 2023
    Review
  14. Article
  15. Article
  16. Epigenomic dynamics of early Xenopus Embryos.Development, growth & differentiation · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hui ChenDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Matthew C GoodDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: mattgood@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

Regulation of the Timing and Spatial Patterning of Zygotic Genome Activation During EmbryogenesisR35GM128748 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOOD, MATTHEW CHARLTON · 2018 to 2022
$2.0M
Hierarchical Onset of Germ Layer SpecificationR03HD105802 · NICHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI CHEN, HUI · 2022 to 2023
$159k
NICHD NIH HHS R03 HD105802NIGMS NIH HHS R35 GM128748
6 · The paper itself

Abstract

Early embryo development requires maternal-to-zygotic transition, during which transcriptionally silent nuclei begin widespread gene expression during zygotic genome activation (ZGA).

Indexed as

TranscriptomeZygoteCycloheximideEmbryonic DevelopmentUridineCycloheximideUridine5-ethynyl uridinecell-cycle elongationcell size gradientclick chemistryDNA:cytoplasm ratioearly embryogenesisgerm layernascent transcriptionspatiotemporal patterningzygotic genome activation

Identifiers

PMID36007528
PMCPMC9560990
OpenAlexW4292951308

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.