ArticleAmerican journal of human genetics2022
Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations.
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Article in American journal of human genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- A new perspective on AMD pathogenesis: a sequential Factor H-centered view of complement dysregulation.Frontiers in immunology · 2026Review
- Genome-wide association study identifiesiScience · 2025Article
- A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment.Nature communications · 2025Article
- Urgent Need to Understand and Prevent Gonococcal Infection: From the Laboratory to Real-World Context.The Journal of infectious diseases · 2024Review
- The human factor H protein family - an update.Frontiers in immunology · 2024Review
- Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines.Trends in microbiology · 2023Review
Corrections and comments
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Authors and funding
38 authors at 20 institutions in 9 countries.
Vikrant KumarHuman Genetics, Genome Institute of Singapore, Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore.
Richard B PouwDivision of Pediatric Immunology, Rheumatology, and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Immunopathology, Sanquin Research, Amsterdam, the Netherlands; Landsteiner Laboratory, Amsterdam University Medical Centre, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands.
Matias I AutioHuman Genetics, Genome Institute of Singapore, Singapore, Singapore; Cardiovascular Research Institute, Centre for Translational Medicine, National University Health System, Singapore.
Manfred G SagmeisterDepartment of General Paediatrics, Medical University of Graz, Graz, Austria.
Zai Yang PhuaHuman Genetics, Genome Institute of Singapore, Singapore, Singapore.
Lisa BorghiniHuman Genetics, Genome Institute of Singapore, Singapore, Singapore; Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; GenPoB Research Group, Instituto de Investigación Sanitaria de Santiago, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain.
Victoria J WrightSection of Paediatric Infectious Disease, Division of Infectious Disease, Department of Medicine, Imperial College London, London, UK.
Clive HoggartSection of Paediatric Infectious Disease, Division of Infectious Disease, Department of Medicine, Imperial College London, London, UK.
Bangfen PanHuman Genetics, Genome Institute of Singapore, Singapore, Singapore; Cardiovascular Research Institute, Centre for Translational Medicine, National University Health System, Singapore.
Antson Kiat Yee TanCancer Stem Cell Biology, Genome Institute of Singapore, Singapore, Singapore.
Alexander BinderDepartment of General Paediatrics, Medical University of Graz, Graz, Austria.
Mieke C BrouwerDepartment of Immunopathology, Sanquin Research, Amsterdam, the Netherlands; Landsteiner Laboratory, Amsterdam University Medical Centre, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands.
Ellie PinnockMicropathology, University of Warwick, Coventry, UK.
Ronald De GrootSection of Pediatric Infectious Diseases, Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Jan HazelzetDepartment of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, University Medical Center, Rotterdam, the Netherlands.
Marieke EmontsTranslational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK; National Institute for Health and Care Research Newcastle Biomedical Research Centre Based at Newcastle Upon Tyne Hospitals National Health Service Trust and Newcastle University, Newcastle Upon Tyne, UK; Paediatric Infectious Diseases and Immunology Department, Newcastle Upon Tyne Hospitals Foundation Trust, Great North Children's Hospital, Newcastle Upon Tyne, UK.
Michiel Van Der FlierSection of Pediatric Infectious Diseases, Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital University Medical Centre Utrecht, Utrecht, the Netherlands.
Karl ReiterDepartment of Paediatrics, Division of Paediatric Intensive Care Medicine, Ludwig Maximilian University of Munich and Dr. von Hauner's Children's Hospital, Munich, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.
EUCLIDS consortium
Luregn J SchlapbachChild Health Research Centre, The University of Queensland, Brisbane, Australia; Paediatric Intensive Care Unit, Queensland Children's Hospital, Brisbane, Australia; Department of Intensive Care and Neonatology and Children`s Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Evangelos BellosSection of Paediatric Infectious Disease, Division of Infectious Disease, Department of Medicine, Imperial College London, London, UK.
Suzanne AndersonMedical Research Council Unit Gambia, Banjul, The Gambia.
Fatou SeckaMedical Research Council Unit Gambia, Banjul, The Gambia.
Federico Martinón-TorresTranslational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain; Genetics, Vaccines, Infectious Diseases, and Pediatrics Research Group, Instituto de Investigación Sanitaria de Santiago, Universidad de Santiago de Compostela, Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Antonio SalasCentro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; GenPoB Research Group, Instituto de Investigación Sanitaria de Santiago, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain.
Colin FinkMicropathology, University of Warwick, Coventry, UK.
Enitan D CarrolInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Andrew J PollardOxford Vaccine Group, Department of Pediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Lachlan J CoinDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
Werner ZenzDepartment of General Paediatrics, Medical University of Graz, Graz, Austria.
Diana WoutersDepartment of Immunopathology, Sanquin Research, Amsterdam, the Netherlands; Landsteiner Laboratory, Amsterdam University Medical Centre, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands.
Lay Teng AngCancer Stem Cell Biology, Genome Institute of Singapore, Singapore, Singapore.
Martin L HibberdInfectious Diseases, Genome Institute of Singapore, Singapore, Singapore; Infectious and Tropical Disease, London School of Hygiene & Tropical Medicine, London, UK.
Michael LevinSection of Paediatric Infectious Disease, Division of Infectious Disease, Department of Medicine, Imperial College London, London, UK.
Taco W KuijpersDivision of Pediatric Immunology, Rheumatology, and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, the Netherlands. Electronic address: t.w.kuijpers@amsterdamumc.nl.
Sonia DavilaHuman Genetics, Genome Institute of Singapore, Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore. Electronic address: gmssmdd@nus.edu.sg.
Imperial College London · GBGenome Institute of Singapore · SGMedical University of Graz · ATSanquin · NLUniversidade de Santiago de Compostela · ESMRC Unit the Gambia · GMNational University Health System · SGRadboud University Nijmegen · NLUniversity of Bonn · DEUniversity of Warwick · GBEmma Kinderziekenhuis · NLErasmus MC · NLLondon School of Hygiene & Tropical Medicine · GBLudwig-Maximilians-Universität München · DENational Health Service · GBNational University of Singapore · SGSingHealth · SGThe University of Melbourne · AUThe University of Queensland · AUUniversity of Liverpool · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neisseria meningitidis protects itself from complement-mediated killing by binding complement factor H (FH). Previous studies associated susceptibility to meningococcal disease (MD) with variation in CFH, but the causal variants and underlying mechanism remained unknown. Here we attempted to define the association more accurately by sequencing the CFH-CFHR locus and imputing missing genotypes in previously obtained GWAS datasets of MD-affected individuals of European ancestry and matched controls. We identified a CFHR3 SNP that provides protection from MD (rs75703017, p value = 1.1 × 10
Indexed as
Complement Factor HMeningococcal InfectionsBlood ProteinsComplement System ProteinsGenetic Predisposition to DiseaseGenotypeHumansBlood ProteinsCFHR3 protein, humanComplement Factor HComplement System ProteinsCFHCFHR3Complementfactor HFactor H-related proteingenotypingin-depth sequencinginfectious diseaseMeningococcal diseaseNeisseria meningitidis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.