Evidence map›Paper›PMID 36007219›Full record

ArticleJCO clinical cancer informatics2022

MTPpilot: An Interactive Software for Visualization of Next-Generation Sequencing Results in Molecular Tumor Boards.

Abdullah Kahraman, Fabian M Arnold, Jacob Hanimann, Marta Nowak, Chantal Pauli, Christian Britschgi, Holger Moch, Martin Zoche

Open access · hybridAbstract read
In one paragraph

Article in JCO clinical cancer informatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Abdullah KahramanDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-3523-4467
Fabian M ArnoldDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-0556-2307
Jacob HanimannDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-3156-0441
Marta NowakDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Chantal PauliDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0001-9621-8511
Christian BritschgiDepartment of Medical Oncology and Hematology, Comprehensive Cancer Center Zurich, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0001-8831-1564
Holger MochDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-7986-2839
Martin ZocheDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
University Hospital of Zurich · CHUniversity of Zurich · CHSIB Swiss Institute of Bioinformatics · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeComprehensive targeted next-generation sequencing (NGS) panels are routinely used in modern molecular cancer diagnostics. In molecular tumor boards, the detected genomic alterations are often discussed to decide the next treatment options for patients with cancer. With the increasing size and complexity of NGS panels, the discussion of these results becomes increasingly complex, especially if they are reported in a text-based form, as it is the standard in current molecular pathology.

methodsWe have developed the Molecular Tumor Profiling pilot (

resultsMTPpilot integrates various public genome, network, and cancer mutation databases with interactive visualization tools to assess the functional impact of mutations and support clinical decision making at tumor boards.

conclusionMTPpilot is tailored for discussion of NGS gene panel results at molecular tumor boards. It is freely available as a webservice at MTPpilot.

Indexed as

High-Throughput Nucleotide SequencingNeoplasmsGenomicsHumansMutationSoftware

Identifiers

PMID36007219
PMCPMC9470140
OpenAlexW4293093181

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.