Evidence map›Paper›PMID 36007090›Full record

ArticleJournal of cognitive neuroscience2023

The Entangled Brain.

Luiz Pessoa

Abstract read
In one paragraph

Article in Journal of cognitive neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Review
  2. Brain Architecture of Punishment Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Music as a scientific metaphor for mind and brain.Neuroscience and biobehavioral reviews · 2026
    Review
  8. Article
  9. Article
  10. Brain glucodynamic variability is an essential feature of the metabolism-cognition relationship.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Luiz PessoaUniversity of Maryland.

Funding

INTERACTION OF EMOTIONAL PERCEPTION AND VISUAL ATTENTIONR01MH071589 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI PESSOA, LUIZ · 2004 to 2024
$8.9M
Dynamics of Large-Scale Networks During Emotional and Social ProcessingR01MH112517 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI PESSOA, LUIZ, REDCAY, ELIZABETH · 2017 to 2021
$3.3M
NIMH NIH HHS MH071589NIMH NIH HHS R01 MH071589NIMH NIH HHS R01 MH112517
6 · The paper itself

Abstract

The Entangled Brain (Pessoa, L., 2002. MIT Press) promotes the idea that we need to understand the brain as a complex, entangled system. Why does the complex systems perspective, one that entails emergent properties, matter for brain science? In fact, many neuroscientists consider these ideas a distraction. We discuss three principles of brain organization that inform the question of the interactional complexity of the brain: (1) massive combinatorial anatomical connectivity; (2) highly distributed functional coordination; and (3) networks/circuits as functional units. To motivate the challenges of mapping structure and function, we discuss neural circuits illustrating the high anatomical and functional interactional complexity typical in the brain. We discuss potential avenues for testing for network-level properties, including those relying on distributed computations across multiple regions. We discuss implications for brain science, including the need to characterize decentralized and heterarchical anatomical-functional organization. The view advocated has important implications for causation, too, because traditional accounts of causality provide poor candidates for explanation in interactionally complex systems like the brain given the distributed, mutual, and reciprocal nature of the interactions. Ultimately, to make progress understanding how the brain supports complex mental functions, we need to dissolve boundaries within the brain-those suggested to be associated with perception, cognition, action, emotion, motivation-as well as outside the brain, as we bring down the walls between biology, psychology, mathematics, computer science, philosophy, and so on.

Indexed as

BrainCognitionEmotionsHumansMotivation

Identifiers

PMID36007090
PMCPMC11019915

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.