ArticleScience (New York, N.Y.)2022
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex.
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Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 3 of them syntheses that pooled it.
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162citing papers in PubMed, 3 pooled it
22.2field-weighted citation impact, top 1% of its field
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Who cites it
162 citing papers in PubMed, 3 syntheses or guidelines pooled it, 267 citations in OpenAlex.
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- Single-nucleus atlas of cell-type specific genetic regulation in the human brain.Nature genetics · 2026Article
- Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis.Cell · 2026Article
- Transcriptome of fetal cortex of tree shrew underlying the emergence of outer subventricular zone.Communications biology · 2026Article
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- Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer's disease.Nature genetics · 2026Article
- Regional specialization of upper-layer inhibitory interneuron organization in the human prefrontal cortex.Journal of anatomy · 2026Article
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- Developmental signaling reveals functionally enriched human-specific gene regulation in telencephalic progenitors.bioRxiv : the preprint server for biology · 2026Article
- Single-nucleus transcriptomics-based drug screening platform for focal cortical dysplasia.Molecular psychiatry · 2026Article
- Genomic sequence evolution underlying human neocortical interareal diversification.Genome biology · 2026Article
- Expression patterns of risk genes associated with three evolutionarily relevant syndromes in rhesus macaque and human brains.Translational psychiatry · 2026Article
- Charting the human-specific properties of gene expression networks in the infant prefrontal cortex.Science advances · 2026Article
- Multidimensional modeling of biological aging: integrating gait, eye movement, rest-state functional connectivity, and plasma biomarkers in non-dementia older adults.The journal of prevention of Alzheimer's disease · 2026Article
- Comparative analysis of the cellular landscape in mammalian striatum.Nature communications · 2026Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 13 institutions in 6 countries.
Shaojie Ma *Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-8782-3047
Mario Skarica *Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-2478-014X
Qian LiDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Chuan XuDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Ryan D RisgaardWaisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-6240-9843
Andrew T N TebbenkampDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-9015-3427
Xoel Mato-BlancoNeurogenomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), MELIS, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain.ORCID 0000-0003-2155-9922
Rothem KovnerDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-3874-8888
Željka KrsnikDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-5238-6820
Xabier de MartinNeurogenomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), MELIS, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain.ORCID 0000-0003-3823-3291
Victor LuriaDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Xavier Martí-PérezNeurogenomics Group, Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), MELIS, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain.ORCID 0000-0001-5248-9440
Dan LiangDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-7407-3139
Amir KargerIT-Research Computing, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4561-3850
Danielle K SchmidtWaisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Zachary Gomez-SanchezWaisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0001-8684-4543
Cai QiDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Kevin T GobeskeDivision of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA.
Sirisha PochareddyDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-9505-8090
Ashwin DebnathWaisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Cade J HottmanWaisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Joshua SpurrierProgram in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale School of Medicine, New Haven, CT 06536, USA.ORCID 0000-0002-6267-7231
Leon TeoAustralian Regenerative Medicine Institute, 15 Innovation Walk, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0001-6115-1134
Anthony G BoghdadiAustralian Regenerative Medicine Institute, 15 Innovation Walk, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0003-2944-7845
Jihane Homman-LudiyeAustralian Regenerative Medicine Institute, 15 Innovation Walk, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0001-6689-1457
John J ElyMAEBIOS, Alamogordo, NM 88310, USA.
Etienne W DaadiSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.ORCID 0000-0003-2981-6292
Da MiTsinghua-Peking Center for Life Sciences, IDG/McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-7829-1923
Marcel DaadiSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.ORCID 0000-0002-0243-8909
Oscar MarínCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.ORCID 0000-0001-6264-7027
Patrick R HofNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-3208-1154
Mladen-Roko RasinDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0003-3063-6096
James BourneAustralian Regenerative Medicine Institute, 15 Innovation Walk, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-0902-3108
Chet C SherwoodDepartment of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC, USA.
Gabriel SantpereDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-5909-8637
Matthew J GirgentiDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-1647-326X
Stephen M StrittmatterDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-8188-3092
André M M SousaWaisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0003-1740-5066
Nenad SestanDepartment of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-0966-9619
Yale University · USUniversity of Wisconsin–Madison · USAustralian Regenerative Medicine Institute · AUUniversitat Pompeu Fabra · ESGeorge Washington University · USTexas Biomedical Research Institute · USAllen Institute for Brain Science · USCenter for Life Sciences · CNHarvard University · USKing's College London · GBRutgers, The State University of New Jersey · USUnited States Department of Veterans Affairs · USUniversity of Zagreb · HR
Funding
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MThe Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2MSan Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Kelly Renee Reveles · 2015 to 2026
$14.1MM-SCORCH: Methamphetamine use disorder data generation center for Single Cell Opioid Responses in the Context of HIVU01DA053628 · NIDA · YALE UNIVERSITY · PI HO, YA-CHI, SESTAN, NENAD · 2021 to 2025
$9.5MSilent Allosteric Modulation of mGluR5 for Safe and Effective Therapy of Alzheimer's DiseaseU01AG058608 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2018 to 2022
$8.5MWaisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M1/2 Cell Type and Region-Specific Regulatory Networks in Human Brain Development and DisordersU01MH116488 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2018 to 2022
$6.5MIntegrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5MMolecular Diversity Among Hippocampal and Entorhinal Cells in Aging and Alzheimer's DiseaseRF1AG074341 · NIA · YALE UNIVERSITY · PI HUTTNER, ANITA JULIANE, SESTAN, NENAD · 2021 to 2021
$4.9MOverlapping Molecular Dysregulation of Endolysosomal Function in Alzheimer's Disease and FTLD-TDPR01AG066165 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2019 to 2023
$3.9MNCATS NIH HHS UL1 TR001863NHGRI NIH HHS R01 HG010898NHGRI NIH HHS R01 HG011641NIA NIH HHS P30 AG044271NIA NIH HHS P30 AG066508NIA NIH HHS R01 AG066165NIA NIH HHS R56 AG059284NIA NIH HHS RF1 AG074341NIA NIH HHS U01 AG058608NICHD NIH HHS P50 HD105353NIDA NIH HHS U01 DA053628NIGMS NIH HHS T32 GM140935NIGMS NIH HHS T32 GM141013NIH HHS P51 OD011106NIH HHS P51 OD011133NIMH NIH HHS U01 MH116488NIMH NIH HHS U01 MH122678NIMH NIH HHS U01 MH124619NINDS NIH HHS F32 NS117780NINDS NIH HHS R24 NS092988
Abstract
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC. Although most cell subtypes defined transcriptomically are conserved, we detected several that exist only in a subset of species as well as substantial species-specific molecular differences across homologous neuronal, glial, and non-neural subtypes. The latter are exemplified by human-specific switching between expression of the neuropeptide somatostatin and tyrosine hydroxylase, the rate-limiting enzyme in dopamine production in certain interneurons. The above molecular differences are also illustrated by expression of the neuropsychiatric risk gene
Indexed as
Dorsolateral Prefrontal CortexEvolution, MolecularPrimatesSomatostatinTyrosine 3-MonooxygenaseAdultAnimalsDopamineHumansPan troglodytesSingle-Cell AnalysisTranscriptomeDopamineSomatostatinTyrosine 3-Monooxygenase
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