Evidence map›Paper›PMID 36006976›Full record

Observational studyPloS one2022

SARS-CoV-2 infections in infants in Haiti 2020-2021; evidence from a seroepidemiological cohort.

Rigan Louis, Ruiyu Pu, Tracey D Logan, Luke Trimmer-Smith, Richard Chamblain, Adriana Gallagher, Valery Madsen Beau De Rochars, Eric Nelson, Derek A T Cummings, Maureen T Long and 1 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Rigan LouisEmerging Pathogens Institute, University of Florida, Gainesville, FL, United States of America.
Ruiyu PuEmerging Pathogens Institute, University of Florida, Gainesville, FL, United States of America.
Tracey D LoganEmerging Pathogens Institute, University of Florida, Gainesville, FL, United States of America.ORCID 0000-0002-4152-6936
Luke Trimmer-SmithDepartment of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States of America.
Richard ChamblainEmerging Pathogens Institute, University of Florida, Gainesville, FL, United States of America.
Adriana GallagherEmerging Pathogens Institute, University of Florida, Gainesville, FL, United States of America.
Valery Madsen Beau De RocharsEmerging Pathogens Institute, University of Florida, Gainesville, FL, United States of America.
Eric NelsonEmerging Pathogens Institute, University of Florida, Gainesville, FL, United States of America.
Derek A T CummingsEmerging Pathogens Institute, University of Florida, Gainesville, FL, United States of America.
Maureen T LongEmerging Pathogens Institute, University of Florida, Gainesville, FL, United States of America.
J Glenn MorrisEmerging Pathogens Institute, University of Florida, Gainesville, FL, United States of America.ORCID 0000-0001-9347-1984
University of Florida · US

Funding

Cross-reactivity of SARS-CoV-2 with coronaviruses isolated from humans in HaitiR21AI164007 · NIAID · UNIVERSITY OF FLORIDA · PI MORRIS, JOHN GLENN · 2021 to 2022
$419k
NIAID NIH HHS R21 AI164007
6 · The paper itself

Abstract

Few data are available on frequency of SARS-CoV-2 infection among very young children in low- to middle-income countries (LMIC), with the studies that are available biased towards higher income countries with low reported infection and seroconversion rates. Between February 2019 and March 2021, 388 dried blood spot (DBS) samples were obtained from 257 children less than 30 months of age as part of a prospective observational cohort study of pregnant women and their infants in Haiti; longitudinal samples were available for 107 children. In a subsequent retrospective analysis, DBS samples were tested by ELISA for antibody targeting the receptor binding domain of the SARS-CoV-2 S1 protein. Over the course of the study, 16·7% of the infants became seropositive. All seropositive samples were collected after March 19, 2020 (the date of the first reported COVID-19 case in Haiti) with the highest hazards measured in August 2020. Sampling date was the only covariate associated with the hazard of seroconversion. Our data provide an estimate of SARS-CoV-2 infection rates among very young children without prior SARS-CoV-2 exposure during the initial pandemic waves in Haiti, and demonstrate that these children mount a detectable serological response which is independent of patient age.

Indexed as

COVID-19Antibodies, ViralChildChild, PreschoolCohort StudiesFemaleHaitiHumansImmunoglobulin GInfantPregnancyProspective StudiesRetrospective StudiesSARS-CoV-2Antibodies, ViralImmunoglobulin G

Identifiers

PMID36006976
PMCPMC9409576
OpenAlexW4293102067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.